He LENG, PostDoc Position | Cited by 273 | of University of Toronto, Toronto (U of T) | Read 6 publications | Contact He LENG

Oct 18, 2023 · We propose that the Spt16-N domain acts as a protein-protein interaction module, enabling FACT to function as a shuttle chaperone in collaboration with Mcm2 and potentially other replisome components for efficient local parental histone recycling and inheritance. In eukaryotic cells, DNA is packaged into chromatin (1).

Nov 27, 2023 · We propose that the Spt16-N domain acts as a protein-protein interaction module, enabling FACT to function as a shuttle chaperone in collaboration with Mcm2 and potentially other replisome components for efficient local parental histone recycling and inheritance. © …

Jun 4, 2021 · Here, we found, for the first time, that the N-terminal domain of its Spt16 subunit interacts with the Set3 histone deacetylase complex (Set3C) and that FACT and Set3C function in the same pathway to regulate gene expression in some settings.

Jan 27, 2017 · Here we show that replication protein A (RPA), an essential replisome component that binds single-stranded DNA, has a role in replication-coupled nucleosome assembly. RPA directly binds free H3-H4.

May 8, 2021 · Here, we found, for the first time, that the N-terminal domain of its Spt16 subunit interacts with the Set3 histone deacetylase complex (Set3C) and that FACT and Set3C function in the same pathway to regulate gene expression in some settings.

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Jan 10, 2022 · Here, we conduct an unbiased proteome-scale screen to systematically uncover human proteins that activate transcription in a natural chromatin context.

Jun 4, 2024 · The Donnelly Centre Postdoctoral Fellow and Research Associate Seminar Series continues with He Leng and Jeremy Lant as our next speakers. Attend in person at the Donnelly Centre on June 4 at 4pm ET.

Here, we found, for the first time, that the N-terminal domain of its Spt16 subunit interacts with the Set3 histone deacetylase complex (Set3C) and that FACT and Set3C function in the same pathway...