HCK is localized in the cytoplasm where it executes its functions as a kinase. In a steady state, HCK remains in an inactive conformation. Upon interaction with stimuli, such as TLR4 or IL-2, [9] [10] C-terminal tyrosine residues of HCK are dephosphorylated by phosphatases, e.g. CD45, and the inactive conformation of HCK is disrupted resulting in HCK activation. [11]

Upon activation, HCK engages a range of downstream signaling pathways that mediate various aspects of the immune response (Table 1).Critical roles for HCK in these processes have been demonstrated in mice carrying knock-out alleles (HCK KO) or encoding, as a knock-in mutation, a constitutively active protein with a tyrosine-to-phenylalanine (Y 499 F) …

Mar 30, 2025 · HCK (HCK Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with HCK include Autoinflammation With Pulmonary And Cutaneous Vasculitis and Periodic Fever Syndrome.Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and Regulation of …

Jul 18, 2023 · Renal inflammation and fibrosis are the common pathways leading to progressive chronic kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as upregulated in human ...

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils.

Oncomine and CCLE analysis of HCK expression in breast cancer. A: The level of HCK mRNA transcripts in different tumor types. The graph shows the number of datasets with statistically significant mRNA target genes (cancer to non-cancer tissue, cancer to cancer) with increased (red) or reduced expression (blue).

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration.

Apr 1, 2023 · Hck is a member of the vertebrate SRC family of nRTKs, which additionally includes Src, Yes, Fyn, Fgr, Blk, Lck, Lyn, and Yrk [5], [6].Notabaly, only eight of them have been found in human genome, as YRK is a Yes-related kinase that is expressed in chickens [7].SRC family are characterized by five domains: the N-terminal domain, three highly conserved Src homologous domains (SH3, SH2, and SH1 ...

Background: IL-13 promotes alternative activation (M2 polarization) in monocytes. Results: IL-13 induces activation of Src family kinase Hck, which is required for M2 gene expression, including 15-lipoxygenase. Conclusion: Hck acts as a key regulator controlling gene expression in alternatively activated monocytes/macrophages. Significance: A potential new role of Src family kinase Hck in M2 ...

Mar 4, 2022 · Results. We identified 624 TME-associated DEGs and found that HCK was the most promising biomarker associated with AML. The results of the gene set enrichment analysis (GSEA) indicated that HCK was mainly involved in immune and …