p300 HAT functions as histone acetyltransferase [6] that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and differentiation. It …

The p300/CBP HATs have larger HAT domains (about 500 residues) than those present in the GNAT and MYST families. [7] They also contain a bromodomain as well as three …

May 12, 2021 · Loss of β cell identity and functional immaturity are thought to be involved in β cell failure in type 2 diabetes. CREB-binding protein (CBP) and its paralogue p300 act as …

Oct 15, 2018 · We describe a crystal structure of p300 in which the autoinhibitory loop invades the active site of a neighbouring HAT domain, revealing a snapshot of a trans -autoacetylation …

Dec 15, 2022 · We investigate the solution behaviour of the complex and find that interaction with the TAZ2 domain stimulates p300 HAT activity.

May 3, 2022 · We found that HATs (histone acetyltransferases) p300 and CBP (CREB-binding protein) perform nonoverlapping and opposing roles in vascular smooth muscle cell plasticity.

Dec 2, 2007 · The transcriptional coactivator p300/CBP (CREBBP) is a histone acetyltransferase (HAT) that regulates gene expression by acetylating histones and other transcription factors. …

May 28, 2010 · p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation. Based on a p300 structure, Bowers et al. (2010) have conducted an in silico …

Oct 11, 2019 · The focus of this work is the inhibition of histone acetyltransferase p300, a master transcriptional regulator. P300 is an ∼2400AA multidomain protein whose catalytic core …

Jan 31, 2024 · Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transformation in humans, suggestive of a checkpoint of leukocyte compartment …