The Hartford Nomogram method utilizes high-dose, once daily dosing to optimize the peak/MIC ratio in most clinical situations by administering a dose of 7mg/kg of either gentamicin or tobramycin.

Apr 8, 2012 · The Hartford nomogram was one of the first published extended-interval nomograms. Unlike other nomograms, it uses the highest dose of gentamicin/tobramycin (7 mg/kg versus 5 mg/kg), which achieves a 40% higher peak.

• Gentamicin is monitored using the Hartford nomogram which relates observed concentration to the time post dose within a given concentration range. • Follow separate guidance when using gentamicin for Surgical Prophylaxis or in Endocarditis, Pregnancy, Cystic Fibrosis, Renal Unit inpatients or patients on dialysis

Sep 16, 2016 · Before we get too far, let’s clarify what drugs fall in the aminoglycoside class. That way we’re all on the same page. When we talk about aminoglycosides, we’re referring to gentamicin, tobramycin, and amikacin.

Use the Appropriate Barnes-Jewish Nomogram according to the dosing method. Instruction is the same for both Nomograms: Obtain a random level 10 - 12 hours after dosing

Hartford Nomogram for gentamicin/tobramycin 7 mg/kg Q48h Q36h Time start or infusion and sample draw (hrs) FIG. I. ODA nomogram for gentamicin and tobramyi2.in at 7 mykg.

Oct 29, 2024 · The Hartford Nomogram is designed to optimize the dosing of aminoglycosides, antibiotics effective against gram-negative bacteria. This tool is valuable in clinical settings where precise dosing is essential.

Jul 25, 2016 · The 7 mg/kg dose uses the Hartford nomogram for interval adjustment. If patient is started on either gentamicin or tobramycin and has a UTI, open fracture/surgery prophylaxis, cystitis, wound infections, pyelonephritis, or intraabdominal/pelvic infection, 5 mg/kg is warranted.

The Hartford nomogram suggests dividing an amikacin concentration by 2 to plot onto this gentamicin/tobramycin graph.

The three interval break points on the Hartford interval adjustment nomogram are the approximate decay curves from a 7mg/kg gentamicin dose.