Aug 6, 2018 · In assessing UV-induced photobiological damage, we investigated dose-dependent effects of UVB irradiation on human keratinocyte cells (HaCaT). Our study implemented survival and apoptosis assays and revealed an unexpected dose response wherein higher UVB-dosage induced higher viability.

Dec 11, 2021 · This study discovered that curcumin significantly promoted Nrf2 accumulated in the nucleus of UV-treated Hacat cells, and the Nrf2 nuclear accumulation levels in Hacat cells was higher after UVA irradiation compared to UVB irradiation.

In the current study, we sought to characterize the changes in the expression of ORs in the HaCaT human keratinocytes cell line exposed to ultraviolet (UV) light or inflammation, well-recognized stimulus for skin barrier disruption.

UV irradiation and hydrogen peroxide stimulation can induce oxidative stress in human immortalized epidermal keratinocytes (HaCat) and HDFs, as evidenced through elevated levels of ROS and ...

UVB-induced oxidative stress is regulated by the activities of catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) [9]. CAT is a crucial enzyme in the organism’s antioxidant defense system, while SOD is an important free radical scavenger.

Jan 25, 2024 · In this paper, we will establish a stable human keratinocyte (Hacat) cell model of photoaging and inflammation, study the alleviating effect of Dox on this model, and preliminarily screen the related signaling pathways.

Sep 9, 2015 · We demonstrate that UVB-transformed HaCaT cells gain enhanced proliferation rate, apoptosis-resistance and colony- and sphere-forming abilities in a progressive manner. Moreover, these cells...

Conclusively, curcumin protects Hacat cells against UV exposure-induced photo-damage by regulating Nrf2 expression. Keywords: Curcumin; nuclear factor erythroid 2-related factor 2; oxidative stress; photo-damage; skin; ultraviolet.

Art treatment suppresses cell apoptosis and promotes proliferation of UV-irradiated HaCaT cells by increasing β-catenin expression. Our flow cytometry results showed that silencing β-catenin induced by sh-β-catenin or XAV-939 markedly exacerbated the …

Mar 29, 2025 · Myricaria paniculata, a Tibetan plant growing at 2000–4500 m, has anti-inflammatory, antioxidant, and immune-boosting effects and can protect skin cells from Ultraviolet B (UVB)damage. The...