The key labware or testing vessel of HTS is the microtiter plate, which is a small container, usually disposable and made of plastic, that features a grid of small, open divots called wells. In general, microplates for HTS have either … See more

Automation is an essential element in HTS's usefulness. Typically, an integrated robot system consisting of one or more robots transports … See more

Unique distributions of compounds across one or many plates can be employed either to increase the number of assays per plate or to reduce the variance of assay results, or both. The simplifying assumption made in this approach is that any N compounds … See more

• Chemoproteomics
• Compound management
• DNA-encoded chemical library
• Drug discovery hit to lead
• Dual-flashlight plot See more

To prepare for an assay, the researcher fills each well of the plate with some biological entity that they wish to conduct the experiment upon, such as a protein, cells, or an animal embryo. After some incubation time has passed to allow the biological matter to … See more

With the ability of rapid screening of diverse compounds (such as small molecules or siRNAs) to identify active compounds, HTS has led to an explosion in the rate of data … See more

HTS is a relatively recent innovation, made feasible largely through modern advances in robotics and high-speed computer … See more