Herpes simplex virus infection usually causes only annoying, recurring blisters in healthy adults but can cause severe infection in newborns. Newborns may become infected at birth or after birth. The main symptom is a rash of blisters. The diagnosis is typically based on tests of samples taken from the blisters. Many untreated children die.

Neonatal herpes simplex virus (HSV) infection has high mortality and significant morbidity. Incidence estimates range from 1/3,000 to 1/20,000 births. HSV type 2 causes more cases than HSV type 1. HSV is usually transmitted during delivery through an infected maternal genital tract.

Neonatal HSV (NHSV) infection affects approximately 1500 infants yearly (1, Kimberlin). Intrauterine infections account for less than 5% of cases with intrapartum acquisition accounting for >75% of cases.

Jun 28, 2024 · It’s possible for babies to get cold sores if they’re exposed to the herpes simplex virus (HSV). This virus can make newborns very sick. Contact a healthcare provider if you believe your baby was exposed or you notice symptoms.

Nov 14, 2022 · Herpes simplex virus (HSV) infection during pregnancy poses a significant risk to the developing fetus and newborn. Neonates can acquire HSV infection by intrauterine, perinatal, or postnatal transmission of the virus; most cases are acquired perinatally.

Transmission of HSV infection to an infant during the first 4–6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.

Most HSV infections in newborns are caused by HSV-2 that the infant catches from the mother's birth canal. Newborns can sometimes get HSV-1 from close contact with someone who is shedding HSV-1 virus in their saliva or has an active HSV-1 outbreak (cold sores).

Feb 1, 2018 · Herpes simplex virus (HSV) is among the most severely debilitating viruses that can infect the neonate, and is associated with significant mortality and morbidity. Neonatal HSV infection generally is acquired in the peripartum period, and can be devastating if …

Jan 15, 2025 · Neonatal HSV infection causes serious morbidity and mortality and leaves many survivors with permanent sequelae. Strong clinical suspicion, timely diagnosis, and early antiviral treatment are critical to improving outcome.

Apr 21, 2024 · Congenital herpes simplex is a rare but potentially devastating viral infection that occurs in newborns and is transmitted from mother to baby during childbirth. Caused by the herpes simplex virus (HSV), primarily HSV-2, congenital herpes simplex can result in significant morbidity and mortality if not promptly diagnosed and treated.