The HSF1 protein regulates the heat shock response (HSR) pathway in humans by acting as the major transcription factor for heat shock proteins. The HSR plays a protective role by ensuring proper folding and distribution of proteins within cells.

Mar 30, 2025 · HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Diseases associated with HSF1 include Heat-Shock Rna 1 and Lung Cancer. Among its related pathways are Selective autophagy and Cellular response to heat stress.

Mar 7, 2022 · Heat-shock transcription factor 1 (HSF1) orchestrates the fast and vast cellular response to heat shock through increased expression of heat-shock proteins. However, how HSF1 rapidly and...

HSF1 (heat shock factor 1) is an evolutionarily conserved master transcriptional regulator of the heat shock response (HSR) in eukaryotic cells. In response to high temperatures, HSF1 upregulates genes encoding molecular chaperones, also called heat ...

HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia. Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer. HSF1 Protects Sepsis-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome Activation. Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells.

HSF1 is a helix-turn-helix transcription factor that binds to heat shock elements (HSEs) located in the promoters of target genes [4–7]. HSF1 is now increasingly being recognized to play a role in several diseases including cancer and neurodegenerative diseases.

Sep 2, 2024 · Here, we leverage an in vivo model of HSF1 activation and single-cell transcriptomic tumour profiling to show that augmented HSF1 activity in natural killer (NK) cells impairs cytotoxicity,...

Mar 1, 2022 · In this review, we discuss the regulation of Hsf1’s transcriptional activity by multiple layers of control circuits involving Hsf1 synthesis and degradation, conformational rearrangements and post-translational modifications (PTMs), and molecular chaperones in …

Dec 28, 2024 · Heat shock factor 1 (HSF1) is the critical orchestrator of cell responses to heat shock, and its dysfunction is linked to various diseases. HSF1 undergoes phase separation upon heat shock,...

Jan 15, 2014 · Heat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes.