Pulsed Dipolar Spectroscopy (PDS) methods of Electron Paramagnetic Resonance (EPR) were used to detect and characterize reversible non-covalent dimers of Human Serum Albumin (HSA), the most abundant protein in human plasma.

Aug 5, 2021 · Recently, we demonstrated that HSA dimer (HSA-d) possesses a higher tumor distribution than HSA monomer (HSA-m). Therefore, HSA-d is more suitable as a drug carrier for antitumor therapy and can improve nab technology.

Recently, we demonstrated that HSA dimer (HSA-d) possesses a higher tumor distribution than HSA monomer (HSA-m). Therefore, HSA-d is more suitable as a drug carrier for antitumor therapy and can improve nab technology.

Aug 10, 2015 · Human serum albumin (HSA) undergoes several structural alterations affecting its properties in pro-oxidant and pro-inflammatory environments, as it occurs during liver cirrhosis. These modifications include the formation of albumin dimers.

HSA dimers occur at physiological pH values and HSA concentration; dimers exit the blood vessels into the extravascular fluids, which contain much lower levels of monomeric HSA, thus favoring dimers dissociation and shifting the equilibrium toward higher levels of monomers compared to dimers [47,48].

May 9, 2012 · In this review, we summarize the structural characteristics of recombinant albumin dimers produced by two methods, namely, chemical linkage with 1,6-bis (maleimido)hexane and genetically linked with an amino acid linker, and the physicochemical characteristics and biological properties of these preparations.

Nov 10, 2015 · In this study, we investigated the influence of SNO-HSA-Dimer on the anti-tumor effect of two types of macromolecular anti-tumor drugs, namely N-(2-hydroxypropyl)methacrylamide polymer conjugated with zinc protoporphyrin, which forms micelles and can be used for fluorescence studies.

We previously showed that human serum albumin (HSA) dimerized at the protein's Cys34 by 1,6-bis (maleimido)hexane has longer half-life than the monomer under high permeability conditions. The aim of this study was to investigate the superior ability of this HSA dimer as a plasma-retaining agent for fatty acid conjugated antidiabetic drugs.

Dec 1, 2015 · Human serum albumin (HSA) dimer was synthesized in a reaction of the monomer with 1,6-bis (maleimido)hexane (BMH) cross-linker. Thorough physicochemical characteristics of the dimer were performed.

Dec 29, 2020 · Pulsed Dipolar Spectroscopy (PDS) methods of Electron Paramagnetic Resonance (EPR) were used to detect and characterize reversible non-covalent dimers of Human Serum Albumin (HSA), the...