Container Closure Integrity Testing (CCIT) using laser-based headspace analysis with Tunable Diode Laser Absorption Spectroscopy for precise leak detection.

LIGHTHOUSE technology enables container closure integrity testing (CCIT) by detecting gas exchange through even the smallest defects. From products stored at room temperature down to cryogenic conditions, LIGHTHOUSE analyzers deliver reliable CCIT for a wide range of packages and products throughout their product life-cycle.

Laser-based Headspace Analysis (HSA) is an established technology than can be applied to various inspection tasks related to container closure integrity testing (CCIT) as well as process control. HSA is based on laser absorption spectroscopy and measures gas concentrations non-destructively in various package types such as vials, ampoules ...

Jan 15, 2019 · Container closure integrity testing (CCIT) is necessary to confirm the integrity of a container closure system (CCS), until the end of a products’s shelf life. The new and revised United States Pharmacopeia (USP) informational chapter <1207> is a …

Oct 23, 2018 · This paper will present a simple approach to be used in method validation of a CCIT method based on headspace oxygen analysis for freeze dried biopharmaceutical drug products in vials, as well as a method for testing and verifying positive control vials.

LIGHTHOUSE offers solutions for Container Closure Integrity Testing (CCIT), Oxygen Monitoring, and Moisture Determination.

The WILCOMAT ® HSA-Lab is a system for the non-destructive measurement of gas concentrations such as oxygen and carbon dioxide in the headspace using laser absorption spectroscopy. It can test vials, syringes and ampoules or other packaging used for sterile pharmaceuticals.

The HSA Lab Series is equipped with our 3rd generation of TDLAS (tunable diode laser absorption spectroscopy) providing industry leading sensitivity for the non-destructive Headspace Analysis of pharmaceutical packaging.

Dec 16, 2022 · The VialArch™ headspace analysis (HSA) module uses Gasporox’s Swedish-developed Tuneable Diode Laser Absorption Spectroscopy (TDLAS) technology that passes a laser beam through the gas headspace of moving vials to perform non-destructive measurements of the residual gas composition and any pressure deviations for 100% quality and CCIT ...

Using appropriate Container Closure Integrity Testing (CCIT) methods can significantly lower the risk of such defects, therefore minimizing contamination. Various regulatory bodies have established guidelines for proper CCIT.