Apr 14, 2021 · Our work identifies HP1a as an epigenetic regulator that is involved in establishing the global structure of the genome in the early embryo. In metazoans, fertilization triggers …

Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing to gene regulation through a variety of molecular …

Jul 14, 2021 · Here, we analyzed high-resolution ChIP-Seq and ChIP-chip maps of all the somatic Drosophila HP1 family members in three different cell-types, which raise interesting points …

Jul 1, 2014 · The ChIP-seq together with the LC-MS/MS results of the HIPP1-BioTAP pull-down suggest that the protein associates with HP1a within heterochromatin and also plays an HP1a …

May 24, 2024 · Here, we examine the roles of HP1a and methylated histone H3 lysine 9 (H3K9), two hallmarks of constitutive heterochromatin, in determining 3D genome organization during …

Here, by combining chromosome conformation capture (Hi-C), chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq), 3D DNA fluorescence in situ hybridization (3D …

Mar 13, 2019 · Our findings demonstrate that HP1 is required intrinsically to promote GSC self-renewal and progeny differentiation by directly stabilizing the transcripts of key genes involved …

Aug 9, 2020 · The HP1a and HIPP1 proteins co-localize at the Fub insulator (the first violet box) in the Abd-a gene along with CP190, Su (Hw), CTCF, and Mod (mdg4), and Ibf 1 and 2. From …

Heterochromatin protein 1 (HP1a in Drosophila) is a conserved eukaryotic chromosomal protein that is pro-minently associated with pericentric heterochromatin and mediates the concomitant …

Aug 2, 2013 · Drosophila melanogaster Heterochromatin Protein 1a (HP1a) is an essential protein critical for heterochromatin assembly and regulation. Its chromo shadow domain (CSD) …