Feb 25, 2022 · In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop...

HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released from cells, an extracellular form in which it may bind to toll-like receptors (TLRs) or an inflammatory receptor called the receptor for advanced glycation end-products RAGE.

High Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis.

In AIS patients, large amounts of HMGB1 are secreted by ischemic brain tissue and released extracellularly to promote an inflammatory response to exacerbate brain damage, and large amounts of HMGB1 can also be detected in ischemic brain tissue in the chronic phase. 26, 27 Elevated HMGB1 can further activate platelets and induce thrombosis ...

High-mobility group box 1 (HMGB1) protein is a member of the highly conserved non-histone DNA binding protein family. First identified in 1973, as one of a group of chromatin-associated proteins with high acidic and basic amino acid content, it was ...

Aug 8, 2024 · Notably, nuclear, but not secreted, HMGB1 supports the expression of IFN-γ in CD8 T cells via directly regulating the activity of Eomes, the transcription factor for IFN-γ. Functional study shows that HMGB1 promotes the anti-tumor ability of CD8 T cells in vitro and in vivo.

Jun 15, 2023 · Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its subcellular or...

Sep 26, 2023 · HMGB1 plays a crucial role in tumor growth and response to therapy and promotes both cell death and survival. HMGB1 involves different pathways associated with cancer development and progression. HMGB1 inhibition can enhance response to immune checkpoint blockade in cancer.

Nov 23, 2024 · High Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis.

Feb 20, 2021 · High mobility group box 1 protein (HMGB1) is a ubiquitous, highly conserved nuclear protein that can be detected intra- and extracellularly, orchestrating various site-specific functions.