HMGB1 exerts a crucial regulatory influence on key biological processes including cell survival, inflammatory regulation, and immune response. HMGB1 can be released extracellularly from the cell during these processes, where it functions as a pro-inflammation cytokine.

High-mobility group box 1 (HMGB1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory and autoimmune diseases once it is in an extracellular location.

Jun 21, 2021 · High mobility group box 1 (HMGB1) is a non-histone protein predominantly localised in the cell nucleus where it promotes nuclear transcription processes by interacting with DNA (1 – 4). However, HMGB1 can be passively released into the extracellular matrix by dead, dying or injured cells (1 – 4).

Feb 25, 2022 · In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop...

High Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis.

Nov 15, 2024 · Study revealed that the behavioral alterations, oxidative stress inflammation and apoptosis as well as overexpression of HMGB1 was observed in 3-NP administered rats, while the Glyc rescued 3-NP induced changes in rats including restoration of antioxidant enzymes (SOD, GSH) decrease in MDA levels.

Mar 19, 2025 · This nanoplatform is endowed with high glutathione (GSH) depletion efficiency and exhibits highly efficient Fe 2+ and ROS generation capacity, which promotes the accumulation of LPO and subsequently induces ferroptosis. Concurrently, the inhibition of HMGB1 release counteracts the immunosuppressive effects within the tumor microenvironment.

Aug 14, 2024 · Here, we show that Plasmodium HMGB1 has key amino acid changes in box B resulting in the loss of TNF-α stimulatory activity. Site-directed mutagenesis of the critical amino acids in box B with respect to mouse HMGB1 renders recombinant Plasmodium berghei (Pb) HMGB1 capable of inducing TNF-α release.

Dec 21, 2017 · High mobility group box-1 (HMGb1) protein, a nuclear non-histone protein that is released or secreted from the cell in response to damage or stress, is a sentinel for the immune system that plays a critical role in cell survival/death pathways.

2 days ago · As expected, the release of high mobility group box 1 (HMGB1) and decorin (DCN)—damage-associated molecular patterns ... The relative GSH concentration in tissue lysates was measured using a glutathione assay kit (Sigma-Aldrich, MAK517) according to the manufacturer’s instructions. In this assay, 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB ...