Aug 8, 2021 · In preclinical models of nerve injury, HMGB1 levels are increased in the cell bodies of nociceptors residing in the dorsal root ganglia (DRG) (39, 40).

Although originally described as a highly conserved nuclear protein, high-mobility group box 1 protein (HMGB1) has emerged as a danger-associated molecular pattern molecule protein (DAMP) and is a mediator of innate and specific immune responses.

HMGB1 exerts a crucial regulatory influence on key biological processes including cell survival, inflammatory regulation, and immune response. HMGB1 can be released extracellularly from the cell during these processes, where it functions as a pro-inflammation cytokine.

Nov 13, 2012 · Our study demonstrated that etanercept, a TNF-α inhibitor, significantly decreased HMGB1 expression in DRG neuron cells, providing indirect evidence that TNF-α regulates HMGB1 expression in DRG neurons.

Scholl analysis shows that HMGB1 (10μg/ml) significantly increases DRG axon growth (2-way ANOVA; ***p<0.0001 vs. laminin control), particularly at distances close to the neuronal soma (within 250μm) (Fig 7A).

High Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis.

Apr 4, 2025 · Background Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse reaction to chemotherapy with limited treatment options. Research has indicated that neutrophil extracellular traps (NETs) are critical for the pathogenesis of CIPN. LPS/HMGB1 serve as important inducers of NETs. Here, we aimed to target the inhibition of NET formation (NETosis) to alleviate CIPN. Methods ...

Jul 26, 2018 · HMGB1 and RAGE expression were increased in skin and primary sensory (dorsal root ganglion, DRG) neurons of diabetic rats at times when pain behaviour was enhanced. Agonist-evoked TRPV1-mediated Ca 2+ responses increased in cultured DRG neurons from diabetic rats and in neurons from naïve rats exposed to high glucose concentrations.

May 6, 2020 · Interestingly, in isolated and dissociated dorsal root ganglion (DRG) neurons, HMGB1 elicits an intracellular calcium influx mainly in capsaicin-sensitive neurons and increases the electrical excitability of small-to-medium diameter DRG neurons (Feldman, Due, Ripsch, Khanna, & White, 2012).

Dec 11, 2019 · The expression of HMGB1 in neuropathic pain seems also correlated with Sigma-1 receptor (Sigma-1R), a receptor involved in nociception. In fact, STZ treatment induces Sigma-1R and HMGB1 expression in DRG, with increased tactile allodynia and …