Mar 1, 2023 · High mobility group box-1 (HMGB1) is a nuclear regulator of transcription and a driver of necroinflammation in AKI. We hypothesized that HMGB1 would also modulate AKI-CKD transition in other ways.

Oct 15, 2020 · In the nucleus, HMGB1 acts as a chaperone to regulate DNA events including DNA replication, repair and nucleosome stability. While in the cytoplasm, it is engaged in regulating autophagy and apoptosis. A great deal of research has explored its function in the pathogenesis of renal diseases.

High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that reportedly causes kidney injury and other organ damage in rodent acute kidney injury (AKI) models. However, it remains unclear whether HMGB1 is associated with clinical AKI and related outcomes.

This review focuses on the role of HMGB1 in the pathogenesis of different kidney diseases including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy (DN), antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV), clear cell renal cell carcinoma (ccRCC) and both granulomatous and lupus nephritis (GN ...

Dec 5, 2024 · We recently demonstrated that the mineralocorticoid receptor (MR) is activated by the RAGE/Rac1 pathway, contributing to chronic renal damage in hypertensive mice. Therefore, this study investigated the role of the HMGB1/RAGE/MR pathway in AKI and progression to CKD.

High Mobility Group Box Protein-1 (HMGB-1) is a 30-kDa nuclear and cytosolic protein known as a transcription and growth factor, recently identified as a proinflammatory mediator of tissue injury. Recent data implicates HMGB-1 in endotoxin lethality, rheumatoid arthritis, and atherosclerosis.

Oct 15, 2020 · In this review, we focus on the role of HMGB1 in various renal diseases, including acute kidney injury (AKI), chronic kidney disease (CKD), primary glomerulonephritis, nephrotic syndrome, secondary renal diseases (anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, lupus nephritis, diabetic nephropathy and hemolytic uremic ...

HMGB1 participates in multiple key events in CKD progression by activating downstream signals, including renal inflammation, the onset of persistent fibrosis, renal aging, AKI -to-CKD transition, and important cardiovascular complications.

Oct 4, 2016 · Accumulation of HMGB1, VEGF, TNF-α, IL-6, or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD-sepsis, and only part of this effect could be explained by decreased renal clearance. Surprisingly, we found splenic apoptosis in CKD, even in the absence of sepsis.

High Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis.