HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released from cells, an extracellular form in which it may bind to toll-like receptors (TLRs) or an inflammatory receptor called the receptor for advanced glycation end-products RAGE.

Feb 25, 2022 · In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop...

Jun 15, 2023 · Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its subcellular or...

Mar 30, 2025 · HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases associated with HMGB1 include Brachyphalangy, Polydactyly, And Tibial Aplasia/Hypoplasia and Adams-Oliver Syndrome 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

HMGB1, formally known as high-mobility group protein 1 (HMG-1) or amphoterin, was first discovered in 1973 as a chromosomal non-histone protein and named for its high electrophoretic mobility in polyacrylamide gels (Klune, Dhupar, Cardinal, Billiar, & Tsung, 2008).

Sep 26, 2023 · HMGB1 plays a crucial role in tumor growth and response to therapy and promotes both cell death and survival. HMGB1 involves different pathways associated with cancer development and progression. HMGB1 inhibition can enhance response to immune checkpoint blockade in cancer.

HMGB1 is crucial for DNA-containing ICs to induce anti-dsDNA Ab production; HMGB1 acts through the TLR2-mediated and MyD88-dependent miR-155/Ets-1 pathway. HMGB1 distribution is linked to p53 activity and senescence-associated inflammation; High expression of HMGB1 is associated with T-cell lymphoma.

Apr 1, 2005 · HMGB1 is a 'leaderless' cytokine, requiring specialized means to gain access to the immunological synapse or to be secreted. By contrast, after DNA damage as a result of apoptotic cell death,...

High Mobility Group Box 1 (HMGB1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis.

Oct 21, 2020 · HMGB1 (high-mobility group box-1) is a nonhistone DNA-binding protein that is constitutively expressed in most cell types where it resides mainly in the nucleus under physiological conditions 1 and plays an important role in transcription, DNA replication and repair, and nucleosome formation. 2 Posttranslational modifications of the 2 nuclear ...