HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released from cells, an extracellular form in which it may bind to toll-like receptors (TLRs) or an inflammatory receptor called the receptor for advanced glycation end-products RAGE.

Sep 15, 2000 · In the present studies, HMG-1 given intratracheally produced acute inflammatory injury to the lungs, with neutrophil accumulation, the development of lung edema, and increased pulmonary production of IL-1beta, TNF-alpha, and macrophage-inflammatory protein-2.

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes.

Jun 15, 2023 · Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its subcellular or...

The abundant and highly-conserved nucleoproteins comprising the high mobility group-1/2 (HMG-1/2) family contains two homologous basic domains of about 75 amino acids. These basic domains, termed HMG-1 boxes, are highly structured and facilitate HMG-DNA interactions.

The high mobility group box 1 (HMGB1), which belongs to the subfamily of HMG-1/-2, is a highly conserved single peptide chain consisting of 215 amino acid residues with a molecular weight of approximately 24894 Da. HMGB1 is a ubiquitous nuclear protein in mammals and plays a vital role in inflammatory diseases.

Jul 13, 2020 · High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies.

Oct 21, 2020 · HMGB1 (high-mobility group box-1) is a nonhistone DNA-binding protein that is constitutively expressed in most cell types where it resides mainly in the nucleus under physiological conditions 1 and plays an important role in transcription, DNA replication and repair, and nucleosome formation. 2 Posttranslational modifications of the 2 nuclear ...

Sep 15, 2000 · High mobility group protein-1 (HMG-1) 3 is a highly conserved protein with >95% amino acid identity between rodents and humans (7, 8). HMG-1 was initially characterized as a nonhistone nuclear protein that binds to the narrow minor groove of …

Mar 30, 2025 · HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases associated with HMGB1 include Brachyphalangy, Polydactyly, And Tibial Aplasia/Hypoplasia and Adams-Oliver Syndrome 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.