HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. [5] DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of rheumatoid arthritis. [6] [7]

The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this gene and related health conditions.

Mar 30, 2025 · HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

HLA-DRB1*11 may be an immune response-related genetic factor that improve the development of a sustained virological response in patients chronically infected by the HCV-1 genotype and treated with pegylated interferon-alpha and ribavirin; This study indicates a putative association of HLA-DRB1 with moyamoya angiopathy in Caucasian patients.

Association studies of the HLA-DRB1 gene clearly indicate its importance in RA morbidity. This review presents the current state of knowledge on the impact of HLA-DRB1 gene, functioning both as a component of the patient’s genome and as an environmental risk factor.

Although different alleles were associated with particular AIDs, the same allele, HLA-DRB1 ∗ 13, was underrepresented in all of the six diseases analysed. This observation suggests that this allele may confer protection for AIDs, particularly for systemic and rheumatic disease.

HLA-DRB1 is one of several genes in the HLA complex that have been associated with rheumatoid arthritis; variations of this gene are the most significant known genetic risk factor for the disease.