HLA-DR7 (DR7) is a HLA - DR serotype that recognizes the DRB1*0701 to *0705 gene products. The serological reaction of DR7 is excellent for *0701. The serology of *0703 to *0705 to …

HLA-DR is an αβ heterodimer, cell surface receptor, each subunit of which contains two extracellular domains, a membrane-spanning domain and a cytoplasmic tail. Both α and β chains are anchored in the membrane.

HLA-DR7 is a specific genetic phenotype that has been found to be more prevalent in aCL-positive patients in an Italian population compared to aCL-negative patients. AI generated definition based on: Autoantibodies (Third Edition), 2014

To test the hypothesis that closely-related HLA haplotypes containing the DRB1*07:01 gene (“DR7” haplotypes) derived from European and African populations differ in their genetic susceptibility for type 1 diabetes (T1D) depending on the DQ-α molecule present.

We also discovered that HLA-DR7 expression by the donor or HLA-DR17 expression by the recipient decreased susceptibility. We show in this retrospective study that specific donor HLA class II types are important in lung transplantation, because they are associated with either protection from or susceptibility to development of severe BOS.

Serological analysis of mouse L-cell transfectants expressing surface HLA-DR7 molecules, confirmed by antibody binding and allelic sequence comparisons, identified amino acid residues that may be critical to the binding of a monomorphic DR- and DP-specific monoclonal antibody.

Mar 2, 2002 · Within the entire abacavir-exposed cohort (n=200), presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 had a positive predictive value for hypersensitivity of 100%, and a negative predictive value of 97%. Genetic susceptibility to abacavir hypersensitivity is carried on the 57·1 ancestral haplotype.

May 1, 2002 · We first identified several HLA-DR7-restricted class-II epitope candidates in hTRT by examining human T-cell responses to synthetic peptides. We then characterized these HLA-DR7-restricted hTRT epitope candidates by establishing and analyzing peptide-specific T …

Sep 21, 2017 · A whole genome scan study performed on the clinical study material identified a strong genetic association between the major histocompatibility complex alleles for human leucocyte antigens (HLA) (HLA-DR7 and HLA-DQ2) and elevated ALT levels in treated patients.

These data suggest that differential evolutionary mechanisms have acted upon the sequences of the 31 domains of the two active DR p-chain loci since the divergence of the DR4 and DR7 haplotypes. From serological analysis of mouse L-cell may have been derived relatively recently from a common transfectants expressing cell surface HLA-DR7 molecules,