HLA-DR4 (DR4) is an HLA - DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules ...

HLA-DR is an αβ heterodimer, cell surface receptor, each subunit of which contains two extracellular domains, a membrane-spanning domain and a cytoplasmic tail. Both α and β chains are anchored in the membrane.

HLA-DR4, in the context of Neuroscience, refers to a specific haplotype identified by three SNPs that is associated with an increased risk of type 1 diabetes. AI generated definition based on: Molecular Metabolism, 2016

Jun 23, 2021 · Researchers have identified three amino acid residues that are responsible for the variable association of HLA-DR4 subtypes with type 1 diabetes. The human leukocyte antigen (HLA) system is a gene complex in humans that encodes cell-surface proteins responsible for the regulation of the immune system.

A particularly strong association between RA and HLA-DRB1 alleles that encode a HLA-DRβ chain containing a five amino acid sequence motif called the ‘shared epitope’ (SE) has long been documented. 2 Here we review salient immunogenetic, clinical and mechanistic features of RA association with the HLA locus, focusing primarily on the SE.

Nov 3, 2014 · Definition: The major histocompatibility complex locus designated HLA-DR4 was first associated with RA in studies reported by Stastny in 1978. Using the technique of mixed lymphocyte culture, patients with RA were found to be more alike than were normal individuals, suggesting the presence of a shared cell-associated antigen.

Individuals expressing HLA-DR4 bearing the shared susceptibility epitope (SE) have an increased risk of developing rheumatoid arthritis (RA). Posttranslational modification of self-proteins via citrullination leads to the formation of neoantigens that can be …

Apr 25, 2000 · Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA.

In humans, HLA-DR alleles sharing amino acids at the third hypervariable region with DRB1*0401 (shared epitope) are associated with a predisposition to rheumatoid arthritis, whereas DRB1*0402 is not associated with such a predisposition.