HLA-DR is an αβ heterodimer, cell surface receptor, each subunit of which contains two extracellular domains, a membrane-spanning domain and a cytoplasmic tail. Both α and β chains are anchored in the membrane.

HLA-DR refers to a subtype of HLA genes that encode for MHCII molecules, which are responsible for presenting peptides to CD4 receptors and promoting antibody production. It is one of the most polymorphic regions in the human genome and has been extensively studied in relation to neurodegenerative diseases and autoimmune disorders.

HLA-DR antigen specificities (i.e., DR1 to DR18) are determined by the polymorphic DRβ1 chains encoded by DRB1 alleles. HLA haplotypes of certain DRB1 alleles contain specifically linked DRB3 , DRB4 , or DRB5 locus.

HLA-DR molecules are upregulated in response to signaling (reviewed by Lopin et al, 2009) and are a biomarker for immune activation (Newman, 1997).

Mar 7, 2025 · HLA-DR is a MHC (major histocompatibility complex) class II cell surface receptor encoded by human leukocyte antigen complex on 6p21.31 (Wikipedia: HLA-DR [Accessed 3 August 2018])

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups. Serology. DR15, DR2 and other serotype recognition of some DRB1*15 alleles [1] DRB1*

HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. However it can pair with, in any individual, the beta chain from 3 different DR beta loci, DRB1 , and two of any DRB3 , …

Dec 20, 2023 · The Hla Dr gene, also known as the human leukocyte antigen (HLA-DR) gene, is an important gene in the major histocompatibility complex (MHC) class II region. This gene plays a crucial role in the immune system by encoding a protein that is a …

HLA-DR level in cytotoxic T cells is a clinically validated predictive biomarker of breast cancer patients’ response to NACT. (A) Percentage of infiltrating cytotoxic T cells (CTLs) in NACT-responders (black dots, 1st cohort n = 13 and 2nd cohort n = 11) and non-responders (red dots, 1st cohort n = 17 and 2nd cohort n = 20) breast cancer ...

HLA-DR is expressed by approximately one third of effector Tregs in adult human PB. HLA-DR + Tregs express higher levels of FoxP3 and are responsible for contact-dependent in vitro suppression, while the suppression by HLA-DR − Tregs is initially mediated by IL-4 and IL-10 and later by a contact-dependent mechanism [47].