When complexed with antigenic peptides, human leukocyte antigen (HLA) class I (HLA-I) molecules initiate CD8 + T cell responses via interaction with the T cell receptor (TCR) and co-receptor CD8. Peptides are generally critical for the stable cell surface expression of HLA-I …

Mar 30, 2025 · One HLA-A molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction ensures peptide-HLA-A-B2M recognition by CD8-positive T cells only (PubMed:2784196, 9177355).

Mar 28, 2025 · CD8A (CD8 Subunit Alpha) is a Protein Coding gene. Diseases associated with CD8A include Immunodeficiency 116 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are TCR Signaling (Qiagen) and Network map …

T-cell surface glycoprotein CD8 alpha chain (C luster of D ifferentiation 8a), is a protein encoded by CD8A gene. [5] The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.

CD8alphaalpha bound the classical MHC molecules HLA-A*0201, -A*1101, -B*3501, and ... [more] Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures.

Nov 1, 2023 · The MHC-I signaling (HLA − CD8A) interaction was iBCC specific, and CD8A was increased in CD8 + T/NK cells in iBCC (Figure 4 f). Interestingly, we found that MHC-I genes were downregulated in MBCs compared with that in NBCs, whereas Fibs, especially Fib1 and Fib2, had a higher expression of MHC-I genes in iBCC than in ANS ( Figure 4 g and h).

Jun 5, 1997 · CD8alpha(alpha) binds one HLA-A2/peptide molecule, interfacing with the alpha2 and alpha3 domains of HLA-A2 and also contacting beta2-microglobulin. A flexible loop of the alpha3 domain (residues 223-229) is clamped between the complementarity-determining region (CDR)-like loops of the two CD8 subunits in the classic manner of an antibody ...

Nov 20, 2009 · In this study, we investigated whether co-transfer of a signaling deficient CD8 coreceptor would still result in optimal HLA class I restricted functionality of HLA class I restricted TCR engineered CD4 + T cells.

Mar 7, 2011 · The human CD8 functions as a co-receptor for specific T cell recognition, and only one complex structure of human CD8αα binding to HLA-A*0201 has been solved, revealing the molecular basis of CD8 interacting with its ligand pHLA.

Jul 16, 2024 · Tumor cells can express various MHC class I molecules (e.g., HLA-A, HLA-B, and HLA-C) on their surface, which present tumor-specific antigens to CD8 + T cells.