HIF-1α protects against oxidative stress by directly targeting ...
Previous studies indicated that HIF-1α reduces ROS levels via multiple pathways during hypoxia, including: improving the efficiency of complex IV by switching the cytochrome c oxidase subunit COX4-1 to COX4-2; induction of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A, the former shunting pyruvate away from the mitochondria and ...
Hif-1a suppresses ROS-induced proliferation of cardiac ... - PubMed
Feb 3, 2022 · CF-specific deletion of Hif-1a resulted in decreased HIF-1 target gene expression and increased mesenchymal progenitors in uninjured hearts and increased CF activation without proliferation following sham injury, as demonstrated using …
Regulation of hypoxia-inducible factor-1a by reactive oxygen …
Hypoxia-Inducible Factor-1 (HIF-1) has been largely studied for its role in cell survival in hypoxic conditions. The regulation of HIF-1 is a complex process and involves a number of molecules and pathways. Among these mechanisms a direct regulatory role of …
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2
Mar 1, 2024 · Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, orchestrate the cellular hypoxic response, activating genes to increase the oxygen supply and reduce expenditure.
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts ...
We report that cardiac fibroblasts (CFs) and mesenchymal progenitors are more hypoxic than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF-1α), and exhibit increased glycolytic metabolism.
HIF-1-mediated metabolic reprogramming reduces ROS levels …
Jan 23, 2014 · In the present study, we demonstrated that cancer cells transiently upregulated HIF-1 activity during their metastatic colonization after extravasation in the lungs in hypoxia-independent and...
Role of reactive oxygen species in the regulation of HIF-1 by …
Our data indicate a dual redox regulation of HIF-1α protein amount with a constant suppression of HIF-1 target gene expression by ROS. The function and survival of eukaryotic cells depends on a constant and sufficient oxygen supply.
Oxygen versus Reactive Oxygen in the Regulation of HIF-1
It has been proposed that mitochondrial production of ROS derived from respiratory complex III is increased under hypoxia, and these ROS contribute to HIF-1α protein stabilization by inhibiting PHD enzymes.
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α …
Jan 8, 2022 · The protein levels of hypoxia inducible factor 1α (HIF-1α) in primary tumors and circulating tumor cells of CRC patients were detected by immunohistochemistry and immunofluorescence. Stable HIF1A knockdown in cell models was …
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts ...
Nov 10, 2021 · Janbandhu and colleagues explored the role of HIF-1α in cardiac fibroblasts after myocardial infarction. HIF-1α provides a critical braking mechanism against damaging fibroblast expansion, which limits heart recovery, via modulating a …