HIF-1, when stabilized by hypoxic conditions, upregulates several genes to promote survival in low-oxygen conditions. These include glycolysis enzymes, which allow ATP synthesis in an …

HIF-1α (Hypoxia-Inducible Factor-1 Alpha) is a critical regulator of cellular responses to hypoxia and plays dual roles in both adaptive survival and pathological injury during stroke. In the …

Jan 18, 2025 · HIF-1 and HIF-2 are well known and widely described. Although these proteins share a high degree of homology, HIF-1 and HIF-2 have non-redundant roles in cancer. In this …

Mar 30, 2025 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Pheochromocytoma and Retinal Ischemia. Among its …

Jan 6, 2025 · An overview of HIF-1-related drugs that are approved or in clinical trials is summarized, highlighting their potential capacity for targeting HIF-1 in cancer and …

Jun 15, 2005 · Here we show that copper (CuCl 2) stabilizes nuclear HIF-1α under normoxic conditions, resulting in hypoxia-response element (HRE)-dependent reporter gene expression. …

The target genes of HIF-1 encode proteins that increase O 2 delivery and mediate adaptive responses to O 2 deprivation. Despite its name, HIF-1 is induced not only in response to …

The prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) axis is a critically important oxygen-sensing pathway that mediates tissue adaptation to low oxygen environments …

Mar 18, 2025 · Hypoxia-inducible factor-1 (HIF-1), a master regulator of the cellular response to low oxygen, plays a critical role in adaptive and pathological processes, including cancer, …

Apr 24, 2024 · Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon …