HDAC9 (histone deacetylase 9) belongs to the class IIa family of histone deacetylases. This enzyme can shuttle freely between the nucleus and cytoplasm and promotes tissue-specific …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …

As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene …

Histone deacetylase 9 (HDAC9), a member of class II HDACs, regulates a wide variety of normal and abnormal physiological functions. Histones play a critical role in transcriptional regulation, …

Jul 20, 2017 · Taken together, the present results demonstrate that the nucleocytoplasmic translocation of HDAC9 plays a critical role in activity-dependent TC axon branching by …

The translocation of HDAC9 from nucleus to cytoplasm was induced by an increase of spontaneous firing activity in cultured mouse cortical neurons. This nucleocytoplasmic …

May 2, 2003 · The HDAC9 gene encodes multiple protein isoforms, some of which display distinct cellular localization patterns. For example, full-length HDAC9 is localized in the nucleus, but …

Aug 5, 2011 · HDAC9 localized in the nucleus, and its negative regulation of adipogenesis segregates with the N-terminal nuclear targeting domain, whereas the C-terminal deacetylase …

HDAC9 contains a MEF2 binding domain (BD) at the N-terminus, a nuclear localization signal (NLS), a C-terminal catalytic domain (CD) and a nuclear export signal (NES) near the C-terminus.

Class II HDACs (4, 5, 6, 7, 9, and 10) can translocate into the nucleus and respond to certain cellular signals they receive, exhibit tissue-specific expression, and shuttle between the …