HDAC9 (histone deacetylase 9) belongs to the class IIa family of histone deacetylases. This enzyme can shuttle freely between the nucleus and cytoplasm and promotes tissue-specific …

As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene …

Histone deacetylase 9 (HDAC9), like most Class II HDACs, catalyzes the removal of acetyl moieties from the ϵ-amino groups of conserved lysine residues in the N-terminal tail of histones.

Histone deacetylase 9 (HDAC9), a member of class II HDACs, regulates a wide variety of normal and abnormal physiological functions. Histones play a critical role in transcriptional regulation, …

Aug 27, 2020 · HDAC9 (histone deacetylase 9) actions in atherosclerosis. HDAC9 risk alleles can increase HDAC9 expression. HDAC9 interacts with IKKs (inhibitory kappa B kinases), leading …

Sep 1, 2024 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is …

We provide evidence to show that HDAC9 forms a complex with USF1, which accumulates at the C/EBPα gene promoter site and represses gene expression. Upon induction of adipogenic …

Jun 17, 2020 · Genome-wide association studies have identified a prominent role of HDAC (histone deacetylase)-9 in atherosclerosis and its clinical complications including stroke and …

Histone deacetylase (HDAC) is another epigenetic modification that has a critical role in gene expression. HDAC catalyzes acetyl group removal from the histone, resulting in the formation …

We find evidence of HDAC9 activation in medial and neointimal SMCs after ligation and binding of the HDAC9-containing complex to SMC contractile-protein promoters correlated with …