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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
HDAC7: a promising target in cancer - PMC - National Center for ...
Feb 28, 2024 · The N-terminal region contains a nuclear localization signal (NLS) and includes a domain that interacts with members of the myocyte enhancer factor 2 (MEF2) transcription …
- DOI: 10.3389/fonc.2024.1327933
- Published: 2024
- Publication: Front Oncol. 2024; 14: 1327933.
- Author: Cui Liu, Dan Zheng, Xuan Pu, Sijun Li
- HISTONE DEACETYLASE 7 (H…
  The effects of HDAC7 NLS-deletion and catalytic mutation on myogenesis. …
- Post-translational Modificati…
  NLS phosphorylation by Aurora B is conserved in both HDAC4 and HDAC9. …
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https://pmc.ncbi.nlm.nih.gov › articles
Histone deacetylase 7: a signalling hub controlling development ...
Histone deacetylase 7 (HDAC7) is a lysine deacetylase and scaffolding protein that regulates numerous cellular and developmental processes via its multifaceted roles in signal …
Journal of Biological Chemistry
https://www.jbc.org › article › pdf
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Cytoplasmic Sequestration of HDAC7 from Mitochondrial and …
Here we describe the novel discovery that the nuclear encoded Class II human histone deacetylase HDAC7 localizes to the mitochondrial inner membrane space of prostate epithelial …
Studies of HDAC7 NLS
febs.onlinelibrary.wiley.com
CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s
CRM1, 14-3-3 proteins, and CaMK play important roles in trafficking of HDAC7, but the interplay between these proteins in this process is not clearly understood. Here, we show that CRM1 is capable of promoting cytoplasmic localization of wild-type and mutant HDAC7 (S178A/S344A/S479A), which is norma...
Author: Chengzhuo G…
Published: 01 Septem…
Cited By: 26
ScienceDirect
Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation
Class IIa HDACs including HDAC7 play a role in gene expression, cell differentiation, and animal development through their association with transcription factors such as myogenic enhancer factors 2 (MEF2s). In this study, we show that endogenous HDAC7 localizes to both the nucleus and the cytoplasm ...
Published: 2010/10/01
Cited By: 0
Keywords: Nucleocyto…
National Center for Biotechnology Information
HISTONE DEACETYLASE 7 (HDAC7) REGULATES MYOCYTE MIGRATION AND DIFFERENTIATION
Class IIa HDACs including HDAC7 play a role in gene expression, cell differentiation, and animal development through their association with transcription factors such as myogenic enhancer factors 2 (MEF2s). In this study, we show that endogenous HDAC7 localizes to both the nucleus and the cytoplasm ...
Author: Chengzhuo G…
Published: 2010/10
DOI: 10.1016/j.bbamcr.…
National Center for Biotechnology Information
Alternative splicing of HDAC7 regulates its interaction with 14-3-3 proteins to alter histone marks and target gene expression
Gene expression is regulated by many mechanisms that together determine how much protein is made from a particular gene. Examples of such mechanisms include chromatin accessibility, transcription elongation rates, pre-mRNA alternative splicing, mRNA degradation, translation efficiency, and protein d...
Author: Laura M. Agos…
Published: 2023/03/03
DOI: 10.1016/j.celrep.2…
febs.onlinelibrary.wiley.com
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Histone deacetylases (HDACs) catalyse removal of acetyl groups from lysine residues on both histone and non-histone proteins to control numerous cellular processes. Of the 11 zinc-dependent classical HDACs, HDAC4, 5, 7 and 9 are class IIa HDAC enzymes that regulate cellular and developmental process...
Author: Yizhuo Wang, …
Published: 18 March 2…
Cited By: 10
ScienceDirect
Article HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis
We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4+CD8+ double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and negative selection, via the transcription factor MEF2D. HDAC7 is exported from the nucleus during T c...
Published: 2003/05/01
Cited By: 0
Page Count: 12
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
HISTONE DEACETYLASE 7 (HDAC7) REGULATES MYOCYTE …
The effects of HDAC7 NLS-deletion and catalytic mutation on myogenesis. C2C12 myoblasts stably expressing wild-type, mutant HDAC7 (ΔNLS), or HDAC7 (SNA) were grown to 80% …
FEBS Press
https://febs.onlinelibrary.wiley.com › doi › full
CRM1 mediates nuclear export of HDAC7 independently of …
Sep 1, 2006 · Here, we show that CRM1 is capable of promoting cytoplasmic localization of wild-type and mutant HDAC7 (S178A/S344A/S479A), which is normally found in the nucleus. Using …
- Author: Chengzhuo Gao, Xiaofang Li, Minh Lam, Yu Liu, Sharmistha Chakraborty, Hung Ying Kao
- Cited By: 26
- Publish Year: 2006
- Published: 01 September 2006
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Post-translational Modifications Regulate Class IIa Histone …
NLS phosphorylation by Aurora B is conserved in both HDAC4 and HDAC9. HDAC7 Readers should note that HDAC7 amino acid numbering has changed considerably over the years as …
People also ask
What does HDAC7 do?
Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to facilitate the progression of different tumors by exerting deacetylation. In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors.
HDAC7: a promising target in cancer - Frontiers
frontiersin.org
Does HDAC7 (SNA) inhibit C2C12 differentiation?
We found that stable expression of HDAC7 (SNA) still inhibited C2C12 differentiation. The inhibitory effect of HDAC7 (SNA) on differentiation was not due to its higher expression ( Fig. 5E ). These results indicated that the HDAC catalytic activity is not required for HDAC7 to inhibit C2C12 differentiation.
HISTONE DEACETYLASE 7 (HDAC7) REGULATES
ncbi.nlm.nih.gov
Does HDAC7 deacetylate both histones and non-histones?
HDAC7 can deacetylate both histones and non-histones and regulate multiple biological processes through deacetylation (32), such as organismal immunity (3, 4), angiogenesis (6), embryonic development (6), energy metabolism (7) and other physiological processes.
HDAC7: a promising target in cancer - Frontiers
frontiersin.org
Does HDAC7 repress transcription?
This suggests that the N-terminal non-catalytic domain of HDAC7 can potently repress transcription, even when HDAC catalytic activity is defective. A summary of the effect of HDAC7 mutations on C2C12 mycocyte differentiation and migration. A schematic representation of HDAC7 functional domains is shown.
HISTONE DEACETYLASE 7 (HDAC7) REGULATES
ncbi.nlm.nih.gov
Where is HDAC7 located?
HDAC7 is a protein that contains 912 amino acids and is encoded by the HDAC7 gene on human chromosome 12 (20). This protein is abundant in the cardiac, placental, pancreatic, and smooth muscle tissues, and can be located within the cytoplasm or nucleus (21).
HDAC7: a promising target in cancer - Frontiers
frontiersin.org
Does HDAC7 play a role in cell migration?
Cell migration is an important step for myoblast fusion to form myotubes. Our observation that HDAC7 is localized to the actin filaments and plasma membranes suggests that HDAC7 may play a role in cell migration. To test this, we assayed cell migration of the HDAC7 mutant stable cell lines in a migration assay.
HISTONE DEACETYLASE 7 (HDAC7) REGULATES
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https://www.ncbi.nlm.nih.gov › pmc › articles
Alternative splicing of HDAC7 regulates its interaction with 14-3-3 ...
Mar 3, 2023 · Here, we demonstrate that several genes encoding histone-modifying enzymes are alternatively spliced downstream of T cell signaling pathways, including HDAC7, a gene …
ScienceDirect
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Histone deacetylase 7 (HDAC7) regulates myocyte migration and ...
Oct 1, 2010 · The effects of HDAC7 NLS deletion and catalytic mutation on myogenesis. C2C12 myoblasts stably expressing wild-type, mutant HDAC7 (∆NLS), or HDAC7 (SNA) were grown …
- Author: Chengzhuo Gao, Yu Liu, Minh Lam, Hung Ying Kao
- Publish Year: 2010
Frontiers
https://www.frontiersin.org › journals › oncology › articles
HDAC7: a promising target in cancer - Frontiers
Feb 28, 2024 · The N-terminal region contains a nuclear localization signal (NLS) and includes a domain that interacts with members of the myocyte enhancer factor 2 (MEF2) transcription factor family . Class IIa HDACs are critical …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
HDAC7: a promising target in cancer - PMC
Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to …
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HDAC7: a promising target in cancer - PMC - National Center for ...

HISTONE DEACETYLASE 7 (H…

Post-translational Modificati…

Histone deacetylase 7: a signalling hub controlling development ...

Cytoplasmic Sequestration of HDAC7 from Mitochondrial and …

HISTONE DEACETYLASE 7 (HDAC7) REGULATES MYOCYTE …

CRM1 mediates nuclear export of HDAC7 independently of …

Post-translational Modifications Regulate Class IIa Histone …

HDAC7: a promising target in cancer - Frontiers

HISTONE DEACETYLASE 7 (HDAC7) REGULATES

HDAC7: a promising target in cancer - Frontiers

HISTONE DEACETYLASE 7 (HDAC7) REGULATES

HDAC7: a promising target in cancer - Frontiers

HISTONE DEACETYLASE 7 (HDAC7) REGULATES

Alternative splicing of HDAC7 regulates its interaction with 14-3-3 ...

Histone deacetylase 7 (HDAC7) regulates myocyte migration and ...

HDAC7: a promising target in cancer - Frontiers

HDAC7: a promising target in cancer - PMC

Related searches for HDAC7 NLS

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