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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
HDAC7: a promising target in cancer - PMC - National Center for ...
Feb 28, 2024 · HDAC7 facilitates β-catenin redistribution to the nucleus by deacetylating β-catenin and inhibiting its phosphorylation, which results in that the nuclear accumulation of β …
- DOI: 10.3389/fonc.2024.1327933
- Published: 2024
- Publication: Front Oncol. 2024; 14: 1327933.
- Author: Cui Liu, Dan Zheng, Xuan Pu, Sijun Li
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Histone Deacetylases (HDACs): Evolution, Specificity, Role in ...
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Histone deacetylase 7: a signalling hub controlling development ...
Histone deacetylase 7 (HDAC7) is a lysine deacetylase and scaffolding protein that regulates numerous cellular and developmental processes via its multifaceted roles in signal …
Studies of HDAC7 NES
ScienceDirect
Review Article Histone deacetylase complexes: Structure, regulation and function
Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes with deacetylase function are among the epigenetic corepressor complexes in the nucleus that target the epigenome. HDAC-bearing corepressor complexes such as the Sin3 complex, NuRD complex, CoREST complex, and ...
Published: 2024/09/01
Cited By: 0
Keywords: Histone de…
PubMed
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Histone deacetylases (HDACs) catalyse removal of acetyl groups from lysine residues on both histone and non-histone proteins to control numerous cellular processes. Of the 11 zinc-dependent classical HDACs, HDAC4, 5, 7 and 9 are class IIa HDAC enzymes that regulate cellular and developmental process...
Author: Yizhuo Wang
Published: 2023/6
Keywords: HDAC7; cl…
National Center for Biotechnology Information
HISTONE DEACETYLASE 7 (HDAC7) REGULATES MYOCYTE MIGRATION AND DIFFERENTIATION
Class IIa HDACs including HDAC7 play a role in gene expression, cell differentiation, and animal development through their association with transcription factors such as myogenic enhancer factors 2 (MEF2s). In this study, we show that endogenous HDAC7 localizes to both the nucleus and the cytoplasm ...
Author: Chengzhuo G…
Published: 2010/10
DOI: 10.1016/j.bbamcr.…
ScienceDirect
Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation
Class IIa HDACs including HDAC7 play a role in gene expression, cell differentiation, and animal development through their association with transcription factors such as myogenic enhancer factors 2 (MEF2s). In this study, we show that endogenous HDAC7 localizes to both the nucleus and the cytoplasm ...
Published: 2010/10/01
Cited By: 0
Keywords: Nucleocyto…
National Center for Biotechnology Information
HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages
B lymphopoiesis is the result of several cell-commitment, lineage-choice, and differentiation processes. Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the extinction of the previous one. To date, the central role of specific transcripti...
Author: Bruna Barned…
Published: 2013/05
Publication: PLoS Ge…
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Histone deacetylase complexes: Structure, regulation and function
Sep 1, 2024 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Histone deacetylase 7: a signalling hub controlling ... - PubMed
This review focuses on the cell biology of HDAC7, including the regulation of its cellular localisation and molecular mechanisms of action, as well as its associative and causal links …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Alternative splicing of HDAC7 regulates its interaction with 14-3-3 ...
Here, we demonstrate that several genes encoding histone-modifying enzymes are alternatively spliced downstream of T cell signaling pathways, including HDAC7, a gene previously …
People also ask
What is HDAC7 acetylase?
Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC7 - Wikipedia
en.wikipedia.org
Is HDAC7 histone deacetylase associated with HDAC3 in vivo?
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem 276: 35826–35835. Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W et al. (2002). Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell 9: 45–57.
Class IIa histone deacetylases: regulating the regulators
nature.com
Is HDAC7 a deacetylase?
Although HDAC7 has shown to have little intrinsic deacetylase activity, studies have shown that HDAC7 may have various alternative functions related to development, proliferation, and inflammation. One study showed that HDAC7 suppresses proliferation and β-catenin activity in chondrocytes.
HDAC7 - Wikipedia
en.wikipedia.org
Why is HDAC7 important?
Over the last two decades, HDAC7 has been associated with key roles in numerous physiological and pathological processes. Molecular, cellular, in vivo and disease association studies have revealed that HDAC7 acts through multiple mechanisms to control biological processes in immune cells, osteoclasts, muscle, the endothelium and epithelium.
Histone deacetylase 7: a signalling hub controlling ... - PubMed
pubmed.ncbi.nlm.nih.gov
Is HDAC7 a kinase?
HDAC7 has both structural and functional similarity to HDACs 4, 5, and 9, as these four HDACs make up the Class IIa of HDACs in higher eukaryotes. Class IIa HDACs are phosphorylated by calcium/calmodulin dependent-kindase (CaMK) and protein kinase D (PKD) in response to kinase-dependent signaling.
HDAC7 - Wikipedia
en.wikipedia.org
What are HDAC complexes?
HDACs form complexes with closely related transcriptional corepressor scaffolding proteins, NCoR and SMRT . The SMRT/NCoR corepressor complex recruits HDAC3 [43, 107] and class IIa HDACs (HDAC4 , HDAC5 , HDAC7 and HDAC9 ).
Histone deacetylase complexes: Structure, regulation and function
sciencedirect.com
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
HISTONE DEACETYLASE 7 (HDAC7) REGULATES MYOCYTE …
A mutation at the C-terminal NES of HDAC7 inhibits myocyte differentiation. To examine whether altered cellular distribution of HDAC7 affects muscle differentiation, we tested the effects of …
Nature
https://www.nature.com › articles
Class IIa histone deacetylases: regulating the regulators
Aug 13, 2007 · Recently, analysis of the silent information regulator (Sir2) protein in yeast and its homologues in higher eukaryotes (SirT1–7) has revealed a …
Author: Maud Martin, Richard Kettmann, Franck Dequiedt
Publish Year: 2007
Wikipedia
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HDAC7 - Wikipedia
Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. [5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and …
Frontiers
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HDAC7: a promising target in cancer - Frontiers
HDAC7 facilitates b-catenin redistribution to the nucleus by deacetylating b-catenin and inhibiting its phosphorylation, which results in that the nuclear accumulation of b-catenin binds to …
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