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Journal of Experimental & Clinical Cancer Research
https://jeccr.biomedcentral.com › articles
HDAC7 promotes NSCLC proliferation and metastasis via …
To investigate the role of HDAC7 on NSCLC malignant progression, we established HDAC7 overexpression and knockdown NSCLC cell lines with lentiviral infection based on the basal HDAC7 levels of NSCLC cell lines (Fig. S1a). Compared with control groups, HDAC7 overexpression remarkably increased cell … See more
HDAC7 Regulates Cell Proliferation and Metastasis Via FGF18 in NSCLC
To explore the potential mechanisms of HDAC7-enhanced NSCLC progression, the RNA-seq based transcriptome analysis was performed in SK-LU-1 cells to … See more
USP10 Interacts with and Stabilizes HDAC7
We then explored whether the stability of HDAC7 protein is affected by ubiquitination. Firstly, mass spectrometry analysis of recombinant HDAC7 (Flag-HDAC7) in … See more
The Correlation of HDAC7 and FGF18 Expression with NSCLC Prognosis
The data from the Kaplan–Meier plotter database showed that high expression of FGF18 was closely correlated with poor prognosis of NSCLC patients (Fig. 6a). … See more
International Journal of Biological Sciences
https://www.ijbs.com
DNMT3a promotes LUAD cell proliferation and metastasis by …
Jan 27, 2025 · In ESCC, HDAC7 can upregulate tumour progression mediated by WNT5A, regulate the expression of EMT-related molecules such as SNAIL and E-cadherin, and …
PubMed
https://pubmed.ncbi.nlm.nih.gov
HDAC inhibition induces EMT and alterations in cellular iron ...
Increased iron accumulation following HDAC inhibitor mediated EMT is associated with decreased expression of the iron export protein ferroportin, enhanced ROS production, and reduced …
- Author: Thais Oliveira, Evan Hermann, Daniel Lin, Winyoo Chowanadisai, Elizabeth Hull, McKale Montgomery
- Publish Year: 2021
Studies of HDAC7 EMT
PubMed
HDAC inhibition induces EMT and alterations in cellular iron homeostasis to augment ferroptosis sensitivity in SW13 cells
Epithelial-to-mesenchymal transition (EMT) is an essential mechanism for development and wound healing, but in cancer it also mediates the progression and spread of aggressive tumors while increasing therapeutic resistance. Adoption of a mesenchymal state is also associated with increased iron uptak...
Author: Thais Oliveira
Published: 2021/11
Keywords: Epithelial-t…
National Center for Biotechnology Information
Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine
Lately, the targetability of HDACs as an anticancer therapeutic strategy has received a lot of attention and become a subject of increased research activities1. Playing very vital roles in gene expression regulation, uncoiling of the closed ‘supercoiled’ chromatin, thus enhancing chromatin accessibi...
Author: Mao-Hua Cai, …
Published: 2018
Publication: Sci Rep. …
ScienceDirect
HDAC inhibition induces EMT and alterations in cellular iron homeostasis to augment ferroptosis sensitivity in SW13 cells
Epithelial-to-mesenchymal transition (EMT) is an essential mechanism for development and wound healing, but in cancer it also mediates the progression and spread of aggressive tumors while increasing therapeutic resistance. Adoption of a mesenchymal state is also associated with increased iron uptak...
Published: 2021/11/01
Cited By: 0
Keywords: Epithelial-t…
PubMed
HDAC7: a promising target in cancer
Histones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs have a strong connection to the suppression of g...
Author: Cui Liu
Published: 2024/02/28
Keywords: HDAC7; ca…
National Center for Biotechnology Information
HDAC inhibitor suppresses proliferation and invasion of breast cancer cells through regulation of miR-200c targeting CRKL
Histone deacetylases (HDACs) have demonstrated to play vital roles in key steps associated with proliferation, invasion and migration in several cancers [1–3]. The recent studies have indicated that HDAC inhibitors are considered promising novel anticancer drugs, and prove useful in preclinical and ...
Author: Xuehai Bian, Z…
Published: 2018/01
DOI: 10.1016/j.bcp.201…
National Center for Biotechnology Information
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer
Background Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resistance to chemotherapy is the main cause of treatment failure in BLBC. Therefore, ...
Author: Garyfallia Pant…
Published: 2022
Publication: Clin Epige…
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
HDAC inhibition induces EMT and alterations in cellular iron ...
Increased iron accumulation following HDAC inhibitor mediated EMT is associated with decreased expression of the iron export protein ferroportin, enhanced ROS production, and reduced …
Nature
https://www.nature.com › articles
WNT5A promotes the metastasis of esophageal squamous cell
Oct 2, 2021 · We examined the effect of HDAC7 downregulation by infecting EC109 cells overexpressing WNT5A with the HDAC7-RNAi lentivirus to confirm the involvement of HDAC7 …
Springer
https://link.springer.com › article
Differential molecular mechanistic behavior of HDACs in cancer ...
This review highlights and discusses the molecular mechanisms of HDACs by which they regulate cell survival, apoptosis, metastasis, invasion, stemness potential, angiogenesis, and epithelial …
People also ask
How does HDAC3 affect EMT?
In normal tubular epithelial cells, HDAC3 along with other HDACs works closely with TGF-β signaling in enhancing EMT and regulating E-cadherin expression while its knockdown does not affect the expression of EMT markers .
Differential molecular mechanistic behavior of HDACs in cancer
link.springer.com
What is a Hepatobiliary IminoDiacetic Acid Scan(HIDA)?
Dr. Himabindu Sreenivasulu
MBBS · 1 years of exp
A Hepatobiliary IminoDiacetic Acid Scan (HIDA scan) is a medical imaging procedure used to assess the functioning of the gallbladder, liver, and bile ducts. During the scan, a radioactive tracer is injected into a vein. The tracer is taken up by the liver and excreted into the bile, allowing visualization of the bile flow through the bile ducts into the gallbladder and eventually into the small intestine. The scan helps diagnose conditions like gallbladder dysfunction, blockages, or leakage of bile. It's a useful tool for evaluating abdominal pain or suspected gallbladder and bile duct issues. Your doctor can provide more details about the procedure and its implications for your specific situation.
1 more answer
bing.com
Does HDAC7 overexpression promote epithelial–mesenchymal transition (EMT)?
HDAC7 overexpression remarkably enhanced cell migration verified by scratch wound assay and transwell assay (Fig. 2 a and b) and suggested that HDAC7 overexpression promoted the epithelial–mesenchymal transition (EMT) of the cells.
HDAC7 promotes NSCLC proliferation and metastasis via stabilization b…
jeccr.biomedcentral.com
How does HDAC inhibitor mediated EMT affect cell viability?
Increased iron regulatory protein binding activity promotes iron accumulation in mesenchymal cells. Altering cellular iron availability during HDAC inhibitor mediated EMT reduces cell viability. HDAC inhibitor treatment increases cell death following ferroptosis induction.
HDAC inhibition induces EMT and alterations in cellular iron homeostasi…
sciencedirect.com
Does HDAC7 play a role in wnt5a-mediated ESCC progression?
Based on these results,HDAC7 is involved in WNT5A-mediated ESCC progression, and approaches targeting WNT5A and HDAC7 might be potential therapeutic strategies for ESCC.
WNT5A promotes the metastasis of esophageal squamous cell carcino…
nature.com
Does HDAC inhibition induce EMT in SW13 cells?
In this study, we demonstrate that HDAC inhibition induces EMT in SW13 cell through the activation of canonical EMT-driving transcription factors, TGFβ1 and SNAI1. In agreement with previous findings [ 6 ], we show that the more mesenchymal-like SW13+ cells have higher levels of intracellular iron than their epithelial SW13- counterparts.
HDAC inhibition induces EMT and alterations in cellular iron homeostasi…
sciencedirect.com
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition …
Jan 26, 2018 · Our results demonstrate that 48 h treatment of the PANC-1 cells with 1 µM SAHA or TSA significantly inhibited the mRNA expression of HDAC1, HDAC7, HDAC8 and Vimentin, …
Crimson Publishers
https://crimsonpublishers.com › nacs › fulltext
HDAC4 and HDAC7 Promote Breast and Ovarian Cancer Cell …
We found that HDAC4 and HADC7 mRNA are up regulated in MDA-MB-231 and C13* cells. Moreover, target HDAC4 and HDAC7 by TSA or shRNA block MDA-MB-231and C13* …
Crimson Publishers
https://crimsonpublishers.com › nacs › pdf
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HDAC4 and HDAC7 Promote Breast and Ovarian Cancer Cell …
These results reveal a new link between HDACs and EMT in the regulation of breast and ovarian cancer migration. Keywords: Histone deacetylases (HDACs); Epithelial-mesenchymal …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
HDAC inhibition induces EMT and alterations in cellular iron ...
Nov 1, 2021 · HDAC inhibitor mediated EMT alters cellular iron metabolism and redox homeostasis. Increased iron regulatory protein binding activity promotes iron accumulation in …
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HDAC7 promotes NSCLC proliferation and metastasis via …

DNMT3a promotes LUAD cell proliferation and metastasis by …

HDAC inhibition induces EMT and alterations in cellular iron ...

HDAC inhibition induces EMT and alterations in cellular iron ...

WNT5A promotes the metastasis of esophageal squamous cell

Differential molecular mechanistic behavior of HDACs in cancer ...

Differential molecular mechanistic behavior of HDACs in cancer

HDAC7 promotes NSCLC proliferation and metastasis via stabilization b…

HDAC inhibition induces EMT and alterations in cellular iron homeostasi…

WNT5A promotes the metastasis of esophageal squamous cell carcino…

HDAC inhibition induces EMT and alterations in cellular iron homeostasi…

Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition …

HDAC4 and HDAC7 Promote Breast and Ovarian Cancer Cell …

HDAC4 and HDAC7 Promote Breast and Ovarian Cancer Cell …

HDAC inhibition induces EMT and alterations in cellular iron ...

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