Jul 21, 2022 · Documenting the biological consequences of this possible reader function, mutation of a critical acetylation site regulated androgen receptor (AR) transcriptional activation function …

To demonstrate the biological relevance of HDAC7 reader function, we provide evidence that HDAC7 acts as a reader of AR acetylation to activate AR-mediated transcription. According to …

Histone deacetylase 7 (HDAC7) is a lysine deacetylase and scaffolding protein that regulates numerous cellular and developmental processes via its multifaceted roles in signal …

Zhang et al. report evidence for the epigenetic-reader function of histone deacetylase 7 (HDAC7). A model is pro-posed where transcription by androgen receptor (AR) is activated by binding of …

This review focuses on the cell biology of HDAC7, including the regulation of its cellular localisation and molecular mechanisms of action, as well as its associative and causal links …

Oct 1, 2006 · Here, we show that the class II HDAC family member HDAC7 is an efficient corepressor of the androgen receptor (AR). HDAC7 resided in the cytoplasm in the absence of …

Oct 1, 2006 · Here, we show that the class II HDAC family member HDAC7 is an efficient corepressor of the androgen receptor (AR). HDAC7 resided in the cytoplasm in the absence of …

After 48 hr of cell growth, HDAC1, HDAC4 and HDAC7 were immunoprecipitated via the Flag tag from the lysate. HDAC deacetylase activity assay was carried out using the HDAC-GloTM …

Jul 21, 2022 · To demonstrate the biological relevance of HDAC7 reader function, we provide evidence that HDAC7 acts as a reader of AR acetylation to activate AR-mediated transcription. …

HDAC7 has both structural and functional similarity to HDACs 4, 5, and 9, as these four HDACs make up the Class IIa of HDACs in higher eukaryotes. Class IIa HDACs are phosphorylated …