Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. [5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.

Mar 30, 2025 · HDAC7 (Histone Deacetylase 7) is a Protein Coding gene. Diseases associated with HDAC7 include Hematologic Cancer. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and PIP3 activates AKT signaling.

Sep 15, 2024 · HDAC7 promotes the growth of human and mouse AEL cells both in vitro and in vivo through its non-enzymatic functions. Our study provides experimental evidence that TP53 deficiency and...

Aug 2, 2019 · We found that HDAC1 and HDAC3 inhibition or knockdown results in HDAC7 downregulation, which is associated with a decrease in histone 3 lysine 27 acetylation (H3K27ac) at transcription start...

Histone deacetylase 7 (HDAC7) is a lysine deacetylase and scaffolding protein that regulates numerous cellular and developmental processes via its multifaceted roles in signal transduction and gene regulation.

Jan 24, 2023 · The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase HDAC7 in macrophages is a metabolic switch that triages danger signals to enable the most appropriate immune response. …

Feb 8, 2025 · HDAC7 promotes the oncogenicity of nasopharyngeal carcinoma cells by miR-4465-EphA2 signaling axis. MiR-489 inhibited the development of gastric cancer via regulating HDAC7 and PI3K/AKT pathway. HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients.

This review focuses on the cell biology of HDAC7, including the regulation of its cellular localisation and molecular mechanisms of action, as well as its associative and causal links with cancer and inflammatory, metabolic and fibrotic diseases.

Apr 3, 2024 · Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT.

Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to facilitate the progression of different tumors by exerting deacetylation. In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors.