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Nature
https://www.nature.com › articles
Human HDAC6 senses valine abundancy to regulate DNA damage
Nov 20, 2024 · Here we present evidence that human HDAC6 is a valine sensor for regulating DNA damage by dictating TET2-mediated DNA demethylation. To identify the potential sensor …
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alliedacademies.org
Role of histone deacetylases 6 (HDAC6) in cancers.
frontiersin.org
Frontiers | The Role of HDAC6 in Autophagy and NLRP3 Inflammasome
cell.com
HDAC6 at Crossroads of Infection and Innate Immunity: Trends in Immunology
frontiersin.org
Frontiers | Inhibition of HDAC6 Activity Protects Against Endothelial ...
cell.com
HDAC6 at Crossroads of Infection and Innate Immunity: Trends in Immunology
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Tet2 is required to resolve inflammation by recruiting Hdac2 to ...
Sep 17, 2015 · Here we show that Tet2 selectively mediates active repression of interleukin-6 (IL-6) transcription during inflammation resolution in innate myeloid cells, including dendritic cells …
- Author: Qian Zhang, Kai Zhao, Qicong Shen, Yanmei Han, Yan Gu, Xia Li, Dezhi Zhao, Yiqi Liu, Chunmei Wang, X...
- Publish Year: 2015
ScienceDirect
https://www.sciencedirect.com › science › article › pii
HDAC6 regulates DNA damage response via deacetylating MLH1
Apr 12, 2019 · HDAC6 interacts with and deacetylates MLH1 both in vitro and in vivo. Interestingly, deacetylation of MLH1 blocks the assembly of the MutSα–MutLα complex. …
- Author: Mu Zhang, Chen Hu, Niko Moses, Joshua Haakenson, Shengyan Xiang, Daniel Quan, Bin Fang, Zhe Yang, We...
- Publish Year: 2019
Nature
https://www.nature.com › articles
Metabolic regulation of cytoskeleton functions by HDAC6 ... - Nature
Sep 27, 2024 · Our study reveals the primary role of HDAC6 in regulating α-tubulin lactylation, establishing a link between cell metabolism and cytoskeleton functions. Microtubules, a major …
American Society of Hematology
https://ashpublications.org › ...
Histone Deacetylase 6 (HDAC6) Influences T-Cell Activation and …
Nov 15, 2013 · In particular, HDAC6 has recently been characterized as a negative regulator of regulatory T-cell suppressive activity (de Zoeten, Molecular and Cellular Biology, 2011). Here …
- Author: Andressa Sodre Laino, David M Woods, Fengdong Cheng, Hongwei Wang, Eduardo M. Sotomayor
- Publish Year: 2013
sciencedirect.com
https://www.sciencedirect.com › science › article › pii
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 …
Dec 1, 2024 · In addition, histone deacetylase 6 (HDAC6), as a synthetic lethal partner of DNMT3A loss, was identified by utilizing an epigenetic inhibitor library. Interactively, DNMT3A …
People also ask
How is HDAC6 activity measured in HCT116 cells?
H3 and α-tubulin were used as markers for nuclear and cytoplasm, respectively. HDAC6 activity was measured using an Epigenase HDAC Activity/Inhibition Direct Assay kit (Colorimetric) (EpiGentek, P-4034). For detection of HDAC6 and deletion mutant activities, HCT116 cells were transfected with pCDNA3.1-Flag–HDAC6 and the deletion mutants.
Human HDAC6 senses valine abundancy to regulate DNA damage
nature.com
What is a Hepatobiliary IminoDiacetic Acid Scan(HIDA)?
Dr. Himabindu Sreenivasulu
MBBS · 1 years of exp
A Hepatobiliary IminoDiacetic Acid Scan (HIDA scan) is a medical imaging procedure used to assess the functioning of the gallbladder, liver, and bile ducts. During the scan, a radioactive tracer is injected into a vein. The tracer is taken up by the liver and excreted into the bile, allowing visualization of the bile flow through the bile ducts into the gallbladder and eventually into the small intestine. The scan helps diagnose conditions like gallbladder dysfunction, blockages, or leakage of bile. It's a useful tool for evaluating abdominal pain or suspected gallbladder and bile duct issues. Your doctor can provide more details about the procedure and its implications for your specific situation.
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bing.com
What does HDAC6 do?
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins.
HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell
cell.com
Does HDAC6 deacetylate histones?
HDAC6 is the only HDAC that possesses two functional deacetylase domains and a zinc finger (ZnF) motif (Figure 1) [16–18]. In vivo, the enzymatic activity of HDAC6 is exerted on tubulin, heat shock protein 90 (Hsp90) and cortactin substrates; however, in vitro, HDAC6 is also able to deacetylate histones [4,17,18].
HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell
cell.com
How are Tet-on-inducible HDAC6 knockdown cells cultured?
U2OS (D), or H292 (E) Tet-On–inducible HDAC6 knockdown cells were cultured with the Tet-free medium (lane 1) or doxycycline-containing medium (0.5 μg/ml) (lane 2). The cell lysates were immunoprecipitated with an anti-MLH1 antibody, followed by Western blotting with the indicated antibodies.
HDAC6 regulates DNA damage response via deacetylating MLH1
sciencedirect.com
Is HDAC6 a deacetylase?
Countering a role for the deacetylase activity of HDAC6, studies have shown that HDAC6 exerts several functional roles independently of its enzymatic activity, the promotion of lymphocyte migration and chemotaxis being a notable example .
HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell
cell.com
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates …
The point representing HDAC6 is marked by an arrow (log2 fold change = 0.189, −log10 P value = 4). Sustaining HDAC6 expression seems to be another of the end-less strategies put in …
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Cell Press
https://www.cell.com › trends › cell-biology › fulltext
HDAC6: a key regulator of cytoskeleton, cell migration …
HDAC6 directly deacetylates cortactin, favoring its binding to F-actin and suggesting that HDAC6 additionally modulates NIH 3T3 motility through cortactin deacetylation . In osteoclasts, HDAC6 acts as a component of the signaling …
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Tet
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Tet
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
A NOVEL ROLE FOR HISTONE DEACETYLASE 6 (HDAC6) IN THE …
Sep 9, 2014 · Epigenetic modifications of specific genes in the APC play a key role in this process, and among them, histone deacetylases (HDACs) have emerged as key participants. …
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ACS Publications
https://pubs.acs.org › doi
Development of Selective Histone Deacetylase 6 …
Histone deacetylase 6 (HDAC6) is involved in multiple cellular processes such as aggresome formation, protein stability, and cell motility. Numerous HDAC6-selective inhibitors have been developed as cellular chemical tools to …
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Tet
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Tet
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Human HDAC6 senses valine abundancy to regulate DNA damage

Images of HDAC6 Tet

Tet2 is required to resolve inflammation by recruiting Hdac2 to ...

HDAC6 regulates DNA damage response via deacetylating MLH1

Metabolic regulation of cytoskeleton functions by HDAC6 ... - Nature

Histone Deacetylase 6 (HDAC6) Influences T-Cell Activation and …

DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 …

Human HDAC6 senses valine abundancy to regulate DNA damage

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell

HDAC6 regulates DNA damage response via deacetylating MLH1

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell

Mutant p53 upregulates HDAC6 to resist ER stress and facilitates …

Missing:

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HDAC6: a key regulator of cytoskeleton, cell migration …

Missing:

Must include:

A NOVEL ROLE FOR HISTONE DEACETYLASE 6 (HDAC6) IN THE …

Missing:

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Development of Selective Histone Deacetylase 6 …

Missing:

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