Aug 15, 2023 · It was shown that in immortalized bone marrow derived macrophages (iBMDMs) inflammasome assembly is dependent on the deacetylase HDAC6 and the aggresome …

Histone deacetylase 6 (HDAC6) is a large multidomain protein that deacetylates lysine residues on cytoplasmic proteins, influencing numerous cellular processes. Both the catalytic and …

Aug 29, 2022 · HDAC6 is a regulator of multiple vital cellular processes and pathways, which are essential not only for physiological homeostasis, but also account for the various stages of …

Nov 20, 2024 · Here we identify that human histone deacetylase 6 (HDAC6) serves as a valine sensor by directly binding valine through a primate-specific SE14 repeat domain. The nucleus …

Nov 26, 2012 · HDAC6 KO mice show reduced phosphorylation of Akt and extracellular signal-regulated kinase 1/2, which are signalling pathways involved in tumour growth, and lower …

Sep 3, 2018 · A fuller understanding of HDAC6 as a critical regulator of many cellular pathways will help further the development of targeted anti-HDAC6 therapies. Here, we review the …

HDAC6 is a class II subclass b HDAC, mainly localized in the cytoplasm of differentiated cells [16,17]. HDAC6 regulates signaling pathways that are involved in tumor cell growth, survival, …

Aug 18, 2024 · The stabilization of P300 with HDAC6 inhibition proposes a potential shift in therapeutic focus from HDAC6 itself to its interaction with P300. This finding opens new …

HDAC6 affects transcription and translation by regulating heat-shock protein 90 (Hsp90). HDAC6 is required in the formation of stress granule (SG) proteins and is instrumental in SG …

HDAC6 plays an important role in cell migration, cell transformation, and DNA damage response. Our and others' studies have linked HDAC6's functions and HDAC6's regulation to the …