Targeting the MYC interaction network in B-cell lymphoma via …
Sep 6, 2022 · Our findings identified the HDAC6 inhibitor M-100 as a new tool to target MYC-dependent lymphomas. M-100 efficiently prevented lymphomagenesis, and induced apoptosis …
See results only from nature.comNature
We would like to show you a description here but the site won’t allow us.
HDAC6 score: to treat or not …
A study now defines an HDAC6 score to predict the response of patients with …
c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor
May 15, 2017 · Upon HDACi treatment, c-Myc is acetylated at lysine 323 and its expression decreases, leading to TRAIL activation and apoptosis. c-Myc binds to the TRAIL promoter on …
- Author: Angela Nebbioso, Angela Nebbioso, Vincenzo Carafa, Mariarosaria Conte, Francesco Paolo Tambaro, Fran...
- Publish Year: 2017
Targeting Histone Deacetylases 6 in Dual-Target Therapy of Cancer
HDAC6 regulates HSP90 function by deacetylation, thereby affecting the stability of HSP90 client proteins. The inhibition of HDAC6 leads to acetylation of HSP90, which decreases the binding …
- Studies of HDAC6 MYC
c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target …
A microenvironment-mediated c-Myc/miR-548m/HDAC6 …
Nov 1, 2013 · HDAC6 in turn is an upstream effector of the Bim signaling pathway in MCL and other B cell lymphomas. We also show that stroma-mediated drug resistance and growth are …
- Author: Tint Lwin, Xiaohong Zhao, Fengdong Cheng, Xinwei Zhang, Andy Huang, Bijal Shah, Yizhuo Zhang, Lynn C...
- DOI: 10.1172/JCI64210
- Publish Year: 2013
- Published: 2013/11/11
Network-based assessment of HDAC6 activity predicts …
Mechanistically, we have linked the anticancer activity of HDAC6i/s to their ability to induce c-Myc hyperacetylation (ac-K148) promoting its proteasome-mediated degradation in sensitive cancer cells.
- People also ask
HDAC6: A unique HDAC family member as a cancer target
Aug 29, 2022 · Combination treatment of HDAC6-selective inhibitors and ibrutinib leads to suppression of cytoprotective Akt, ERK and c-Myc. Combination treatment works via …
HDAC6 score: to treat or not to treat? | Nature Cancer
Dec 30, 2022 · A study now defines an HDAC6 score to predict the response of patients with breast cancer to the HDAC6 inhibitor ricolinostat and characterizes its anti-tumor effects with …
Targeting the MYC interaction network in B-cell lymphoma via …
Here, we show that inhibition of the histone deacetylase 6 (HDAC6) using the HDAC6 inhibitor Marbostat-100 (M-100) reduces oncogenic MYC levels and prevents lymphomagenesis in a mouse model of MYC -induced aggressive B-cell lymphoma.
Targeting the MYC interaction network in B-cell lymphoma via
Jun 1, 2021 · Here, we report that histone deacetylase 6 (HDAC6) inhibition using the novel inhibitor Marbostat-100 (M-100) specifically alters protein-protein interactions in MYC …
Related searches for HDAC6 MYC
