Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. [5] [6] HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders. [7]

Mar 30, 2025 · HDAC6 (Histone Deacetylase 6) is a Protein Coding gene. Diseases associated with HDAC6 include Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia and Bone Disease. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Selective autophagy.

Nov 20, 2024 · Here we identify that human histone deacetylase 6 (HDAC6) serves as a valine sensor by directly binding valine through a primate-specific SE14 repeat domain. The nucleus and cytoplasm...

We propose that an alteration of HDAC6 early during the disease causes both memory dysfunction and precipitates, since HDAC6 has functional domains for both processes. Epigenetics and histone modifications are crucial events in diseases of cognition, neurodegeneration, and development.

Jul 25, 2016 · Histone deacetylase 6 (HDAC6) is a critical target for drug design because of its role in oncogenic transformation and cancer metastasis, and is unique among all histone deacetylases in that...

HDAC6 is involved within 3 cellular mechanisms able to countervail the accumulation of protein aggregates: 1) the binding to ubiquitinated misfolded proteins, 2) the formation of an aggresome followed by autophagy, and 3) the induction of heat shock proteins (HSPs) (Figure 3).

Aug 29, 2022 · HDAC6 is a regulator of multiple vital cellular processes and pathways, which are essential not only for physiological homeostasis, but also account for the various stages of multistep tumor formation including initiation, promotion, progression and …

Histone deacetylases 6 (HDAC6) has emerged as a promising target for the treatment of various human diseases including cancer, neurodegenerative disease and immunology due to its unique structure, substrate and biological functions.

Feb 9, 2025 · HDAC6: A unique HDAC family member as a cancer target. HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy. The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.

Dec 23, 2020 · Here, we review recent findings and novel conclusions on the role of HDAC6 in neurodegeneration. Selective studies with pan-HDACi are also included. We propose that an early alteration of HDAC6 undermines synaptic transmission, while altering transport and aggregation, eventually leading to neurodegeneration.