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Histone Deacetylase 4 Possesses Intrinsic Nuclear Import and …
Nucleocytoplasmic trafficking of histone deacetylase 4 (HDAC4) plays an important role in regulating its function, and binding of 14-3-3 proteins is necessary for its cytoplasmic retention. …
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researchgate.net
Structure and cellular function of HDAC4. (A) Summary of HDAC4 post ...
boneandjoint.org.uk
The role of histone deacetylase 4 during chondrocyte hypertrophy and ...
cell.com
HDAC4 Governs a Transcriptional Program Essential for Synaptic ...
researchgate.net
Nuclear localization is a prerequisite for HDAC4 sumoylation. ( A ...
researchgate.net
HDAC4 and other class IIa homologues as signal transducers.a | Multiple ...
frontiersin.org
Frontiers | HDAC4 in cancer: A multitasking platform to drive not only ...
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and …
HDAC4 is normally localized to the cytoplasm in brain tissue and cultured cerebellar granule neurons. HDAC4 rapidly translocates into the nucleus in response to low-potassium or …
Frontiers
https://www.frontiersin.org › journals › cellular...
Frontiers | HDAC4 as a potential therapeutic target in ...
Feb 24, 2015 · Among class IIa HDACs, HDAC4 has been described as a potent transcriptional repressor that is able to interact via its N-terminal domain with many different co-repressors, specifically in the brain.
Studies of HDAC4 NLS
ScienceDirect
Nuclear accumulation of histone deacetylase 4 (HDAC4) by PP1-mediated dephosphorylation exerts neurotoxicity in Pb-exposed neural cells
Lead (Pb) is an environmental contaminant that primarily affects the central nervous system, particularly the developing brain. Recently, increasing evidence indicates the important roles of histone deacetylases (HDACs) in Pb-induced neurotoxicity. However, the precise molecular mechanisms involving...
Published: 2020/12/01
Cited By: 0
Keywords: Pb Lead; H…
PubMed
The nuclear localization domain of the MEF2 family of transcription factors shows member-specific features and mediates the nuclear import of histone deacetylase 4
Targeting of myocyte enhancer binding factor 2 (MEF2) proteins to the nucleus depends on a C-terminal bipartite nuclear localization signal (NLS). By expression of green fluorescent protein (GFP)/MEF2 fusion proteins in transfected myoblasts, we show that MEF2C contains an additional 13 amino acids ...
Author: S Borghi
Published: 2001/12
Keywords: National In…
National Center for Biotechnology Information
The Histone Deacetylase HDAC4 Regulates Long-Term Memory in Drosophila
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive function. Here, we investigate the role of HDAC4 ...
Author: Helen L. Fitzsi…
Published: 2013
Publication: PLoS On…
PubMed
Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity
In neurons, dynamic changes in the subcellular localization of histone deacetylases (HDACs) are thought to contribute to signal-regulated gene expression. Here we show that in mouse hippocampal neurons, synaptic activity-dependent nucleo-cytoplasmic shuttling is a common feature of all members of cl...
Author: Friederike Schl…
Published: 2013/03/22
Keywords: National In…
ScienceDirect
Review The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart?
Histone deacetylase (HDAC) family members are important mediators of epigenetic mechanisms in the regulation of memory formation. Recent studies have revealed that Class IIa HDAC family member HDAC4 contributes essential functions to synaptic plasticity and memory as well as other neurological proce...
Published: 2015/09/01
Cited By: 0
Keywords: HDAC4; Hi…
ScienceDirect
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Nuclear accumulation of histone deacetylase 4 (HDAC4
Dec 1, 2020 · HDAC4 harbors two NLS domains and one NES domain, enabling it to shuttle between nucleus and cytoplasm. Whilst NLS2 was found indispensable in directing HDAC4 …
- Author: Xiaozhen Gu, Xiyao Huang, Danyang Li, Nanxi Bi, Xi Yu, Hui-Li Wang
- Publish Year: 2020
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Nuclear Calcium Signaling Regulates Nuclear Export of a Subset of …
Mar 22, 2013 · The dephosphorylation of HDAC4 in the cytoplasm, which can be catalyzed by protein phosphatase PP2A (65, 70, 71), unmasks the intrinsic nuclear localization signal (NLS) …
PubMed
https://pubmed.ncbi.nlm.nih.gov
The nuclear localization domain of the MEF2 family of ... - PubMed
We also show that the NLS present in MEF2 proteins is required for efficient nuclear localization of histone deacetylase 4 (HDAC4). In muscle cells, transfected HDAC4 is largely cytoplasmic …
People also ask
Where is HDAC4 found?
HDAC4 is present in the perikaryial cytoplasm of most neurons but its nuclear localization is variable. In the dentate gyrus, nuclear expression is not detectable, whereas in other areas some neuronal nuclei contain HDAC4 signal whereas others do not .
Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…
pmc.ncbi.nlm.nih.gov
How is HDAC4 cleaved?
HDAC4 is cleaved by caspase-2 and -3 at aspartic acid 289. The caspase-cleaved amino-terminal fragment of HDAC4 containing the nuclear localization signal accumulates in the nucleus, represses transcription and induces cell death and acts as a strong repressor of the MEF2C [41 – 45].
Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…
pmc.ncbi.nlm.nih.gov
What does the N-terminal of HDAC4 reveal?
Moreover, the N-terminal of HDAC4 reveals that the glutamine-rich domain of folds into a straight alpha-helix that assembles as a tetramer . C-terminal zinc-binding domain plays a key role in substrate recognition and in the association of HDAC4 with the HDAC3·N-CoR co-repressor complex.
Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…
pmc.ncbi.nlm.nih.gov
What is HDAC4 physiology?
Physiological functions of HDAC4 HDAC4 plays global roles in the regulation of gene transcription, cell growth, survival and proliferation, and their aberrant expression or activity lead to cancer development.
Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…
pmc.ncbi.nlm.nih.gov
What is HDAC4 -5 -7 -9?
HDAC4, -5, -7 and -9 are defined by their particular bipartite structure (Figure 1a). The so-called HDAC domain is limited to a 400–450 amino acid region located at their C terminus.
Class IIa histone deacetylases: regulating the regulators
nature.com
What causes HDAC4 nuclear translocation?
Heat shock stimulation induced HDAC4 nuclear translocation (Dai et al., 2005), hypoxic conditions, in the presence of HIF-1 α, drive HDAC7 to the nucleus (Kato et al., 2004) and hormone occupancy of the AR induces nuclear transfer of HDAC7 and -4 (Halkidou et al., 2004; Karvonen et al., 2006).
Class IIa histone deacetylases: regulating the regulators
nature.com
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Springer
https://link.springer.com › article
CaMKII and PKA-dependent phosphorylation co-regulate nuclear ...
Feb 15, 2021 · Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription, implicated in the development of heart failure. CaMKII-dependent phosphorylation drives …
- Author: Kathryn G. Helmstadter, Senka Ljubojevic-Holzer, Senka Ljubojevic-Holzer, Brent M. Wood, Khanha D. T...
- Publish Year: 2021
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
The Histone Deacetylase HDAC4 Regulates Long-Term Memory in
Dec 9, 2013 · Here, we investigate the role of HDAC4 in long-term memory formation in Drosophila. We show that overexpression of HDAC4 in the adult mushroom body, an …
Molecular Biology of the Cell
https://www.molbiolcell.org › doi › full
PP2A Regulates HDAC4 Nuclear Import - Molecular …
Nov 28, 2007 · In vitro and in vivo binding studies demonstrate that the N-terminus of HDAC4 interacts with the catalytic subunit of PP2A. HDAC4 is dephosphorylated by PP2A and experiments using okadaic acid or RNA …
springer.com
https://link.springer.com › protocol
Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4)
Jun 1, 2016 · Schematic illustration of HDAC4. This deacetylase contains a nuclear localization signal (NLS) in the N-terminal part, a highly conserved deacetylase domain, and a nuclear …
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Histone Deacetylase 4 Possesses Intrinsic Nuclear Import and …

Images of HDAC4 Nls

Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and …

Frontiers | HDAC4 as a potential therapeutic target in ...

Nuclear accumulation of histone deacetylase 4 (HDAC4

Nuclear Calcium Signaling Regulates Nuclear Export of a Subset of …

The nuclear localization domain of the MEF2 family of ... - PubMed

Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…

Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…

Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…

Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and Biologi…

Class IIa histone deacetylases: regulating the regulators

Class IIa histone deacetylases: regulating the regulators

CaMKII and PKA-dependent phosphorylation co-regulate nuclear ...

The Histone Deacetylase HDAC4 Regulates Long-Term Memory in

PP2A Regulates HDAC4 Nuclear Import - Molecular …

Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4)

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