Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. [5][6] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation /deacetylation alters chromosome structure and affects transcription factor access to DNA.

Among class II HDACs, HDAC4 is implicated in controlling gene expression important for diverse cellular functions. Basic and clinical experimental evidence have well established that HDAC4 performs a wide variety of functions.

HDACs are divided into three distinct classes: I, II, and III, on the basis of size and sequence homology, as well as formation of distinct complexes. Among class II HDACs, HDAC4 is implicated in controlling gene expression important for diverse cellular functions.

Mar 30, 2025 · HDAC4 (Histone Deacetylase 4) is a Protein Coding gene. Diseases associated with HDAC4 include Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies and Chromosome 2Q37 Deletion Syndrome. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

The main achievement of HDACs on histones is to repress transcription and promote the formation of more compact chromatin. There are 18 different HDACs encoded in the human genome. Here we will discuss HDAC4, a member of the class IIa family, and its possible contribution to cancer development.

The HDAC4 gene provides instructions for making an enzyme called histone deacetylase 4. This enzyme is part of a group of related enzymes, called histone deacetylases, that modify proteins called histones.

Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins, including transcription factors.

HDAC4 is a target gene of miR-140 and is involved in miR-140-mediated suppression of osteosarcoma cells. HDAC4 increases endogenous SIRT1 expression by enhancing its sumoylation modification levels; downregulated in sustained virologic responders compared to the spontaneous clearers of Hepatitis C

Dec 10, 2024 · Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter.

Mar 17, 2022 · HDAC4 is a class II HDAC. By searching an EST database for sequences similar to yeast Hda1, followed by screening a cDNA library and PCR, Grozinger et al. (1999) identified cDNAs encoding the class II HDACs HDAC4, HDAC5 (605315), and HDAC6 (300272).