May 10, 2023 · In conclusion, the current study findings support the notion that HDAC2's anticancer role was attributed through YY1 regulation by targeting c-Myc and could act as potential novel candidate biomarker for the lung cancer diagnosis.

Jul 26, 2023 · Overexpression of HDAC2 promotes lung cancer cell migration, whereas shHDAC2 effectively inhibits it. Further investigation revealed that HDAC2 interacts with YY1 and deacetylates Lysine 27...

Jul 26, 2023 · The present study has demonstrated that both trichostatin A (TSA) and sodium butyrate (NaBu) significantly inhibit the invasion and migration of lung cancer cells via Histone deacetylase 2 (HDAC2). Overexpression of HDAC2 promotes lung cancer cell migration, whereas shHDAC2 effectively inhibits it.

Jan 1, 2023 · Yin yang 1 (YY1) bound to HDAC2 and regulated the sensitivity of clear cell renal cell carcinoma (ccRCC) to tyrosine kinase inhibitors in ccRCC [9]. Given that HDAC2 can regulate the expression of various genes, HDAC2 might contribute to the …

Feb 8, 2019 · Mechanistically, miR-500a-5p directly targets HDAC2 and inhibits HDAC2-mediated proliferation in CRC in nude mice. Furthermore, YY1 binds to the promoter of miR-500a-5p and negatively...

Mar 30, 2025 · HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Diseases associated with HDAC2 include Glioma Susceptibility 1 and Mood Disorder. Among its related pathways are RNA Polymerase I Promoter Opening and Constitutive Signaling by …

May 10, 2023 · In conclusion, the current study findings support the notion that HDAC2's anticancer role was attributed through YY1 regulation by targeting c-Myc and could act as potential novel candidate biomarker for the lung cancer diagnosis.

May 10, 2023 · In the present study, qPCR and western bot data revealed that the expression level of HDAC2 and YY1 were upregulated in the cell lines and tumor samples of lung cancer patients.

The acetylated central region of YY1 was a target of active deacetylation by HDAC1 and HDAC2, whereas the C-terminal zinc finger domain was not deacetylated. Acetylation and deacetylation, in turn, had intriguing influences on the sequence-specific …

May 10, 2023 · In conclusion, the current study findings support the notion that HDAC2's anticancer role was attributed through YY1 regulation by targeting c-Myc and could act as potential novel candidate biomarker for the lung cancer diagnosis.