Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. [5] It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …

Oct 2, 2018 · Here we show that Histone Deacetylase 1 and 2 (HDAC1/2), the catalytic core of numerous co-repressor complexes, are important histone decrotonylase enzymes. A ternary …

Sep 1, 2024 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is …

Promising targets are histone deacetylases (HDACs), since they regulate posttranslational protein acetylation. Over a thousand proteins are reversibly acetylated, and acetylation critically …

The crystal structure of the HDAC2-benzamide complex reveals that the inhibitor coordinates to the catalytic Zn 2+ ion through both the carbonyl and amino groups to form an unusual 7 …

Aug 19, 2023 · We report that HDAC2, in collaboration with the specific TGF-β pathway proteins, SMAD3-SKI, regulates chromatin organization and associated transcriptional programs to …

Apr 15, 2021 · These results revealed that the distinct complexes of HDAC2-Sp3 and HDAC2-Sin3A may be selectively inhibited by HDAC2 C-terminal domain administration. Further …

Sep 12, 2018 · HDAC1 and HDAC2 are components of several corepressor complexes (NuRD, Sin3, CoREST and MiDAC) that regulate transcription by deacetylating histones resulting in a …

Mar 30, 2025 · HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Diseases associated with HDAC2 include Glioma Susceptibility 1 and Mood Disorder. Among its related pathways …