Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. [5] It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones (H2A, H2B, H3, and H4).

Mar 30, 2025 · HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Diseases associated with HDAC2 include Glioma Susceptibility 1 and Mood Disorder. Among its related pathways are RNA Polymerase I Promoter Opening and Constitutive Signaling by …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles.

Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses and is often significantly overexpressed in solid tumors. Nevertheless, transformed cells lacking HDAC2 due to …

HDAC2 is responsible for the deacetylation of the N-terminal of histone H3 and H4, leading to a more compacted chromatin structure and transcriptional gene silencing (16,17). HDAC2 participates in the genesis and development of renal, cardiovascular, neurological and lung disease (18–23).

The present review updates details on the structural features, physiological functions, and roles of HDAC2 in different types of cancer, emphasizing the challenges and status of the development of HDAC2 selective inhibitors against various types of cancer.

histone deacetylase 2, YY1-associated factor 1, protein deacylase HDAC2, transcriptional regulator homolog RPD3. HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4B. ACAP3 negatively regulated by HDAC2 inhibits the malignant development of papillary thyroid carcinoma cells.

Nov 4, 2009 · Histone deacetylases control cellular signaling and gene expression. Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses and is often significantly overexpressed in solid tumors.

Histone deacetylase HDAC2 regulates microRNA-125a expression in neuroblastoma. Liu D, et al. Brain Behav, 2022 Feb. PMID 35060363, Free PMC Article. Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides.

Apr 15, 2021 · HDAC2 is a key regulator in gene expression and homeostasis of the cell cycle. Altered expression of HDAC2 leads to the development various types of cancers. Role of HDAC2 in neurodegenerative disorders is also highlighted in this review. Evidence and strategies for selective HDAC2 inhibition are reported in this review.