Activation of BAT and suppression of WAT expansion are two principal treatments of obesity. Our results indicate that HDAC11 deletion suppressed WAT weight in HFD-fed mice compared to WT control animals, which may be largely due to the smaller size of …

Histone deacetylase 11 (HDAC11) belongs to the class IV member of the histone deacetylase (HDAC) family. It is mainly expressed in brain, heart, skeletal muscle, kidney, testis, immune cells and cancer cells. HDAC11 has a molecular weight of 39 kDa. The protein consists of one catalytic domain and is found in a complex with HDAC6.

HDAC11 mediates obesity and metabolic syndrome by regulating adipogenesis, increasing energy consumption and promoting lipid metabolism. It also contributes to adipose tissue inflammation by regulating immune responses and insulin resistance. HDAC11 was shown to have inhibitory roles in the development of diabetic cardiovascular disease.

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. [5] [6] It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II. [7]

They show that HDAC11 KO mice are resistant to high-fat diet-induced obesity. Deletion of HDAC11 decreases liver damage and enhances glucose tolerance, uncovering important contribution(s) of HDAC11 in livers.

Know comprehensive HDAC11 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Apr 23, 2021 · HDAC11 is present in all eukaryotes except fungi and is a highly conserved protein (human HDAC11 is 91% identical to mouse, 52% to Drosophila, and 51% to Arabidopsis) [[6]]. At 347 amino acids and with a molecular weight of 39.1 kilodalton (kDa), HDAC11 is …

Nov 1, 2020 · HDAC11 is the latest member of histone deacetylase family. HDAC11 is closely associated with tumor development and prognosis. HDAC11 is involved in the biological functions of almost every system of the human body. Highly selective inhibitors are essential to study the biological function of HDAC11.

Monoclonal Anti-Histone Deacetylase 11 (HDAC11) recognizes human HDAC11 (approx. 39 kDa). The antibody epitope resides within amino acids 2-16 of human HDAC11. The antibody may be used in ELISA and immunoblotting.

Here, we reportthatHDAC11 knockout mice are resistant to high-fat diet-induced obesity and metabolic syndrome, suggesting that HDAC11 functions as a crucial metabolic regulator.