HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells. HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells.

Here, we summarize the importance of HDAC11 in a vast array of cellular pathways, which has been recently highlighted by discoveries about its subcellular localization, biochemical features, and its regulation by microRNAs and long noncoding RNAs, …

Mar 12, 2022 · HDAC11 knockdown mitigated pyroptosis by suppressing both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways in TNF-α-induced HUVECs.

Oct 1, 2023 · Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In recent years, research on the role of HDAC11 in tumors has attracted increasing attention.

Sep 3, 2023 · This review summarizes the current knowledge on the subcellular localization, structure, expression, and functions of HDAC11 in tumors, as well as the regulatory mechanisms involved in its network, including ncRNA and substrates.

Dec 25, 2024 · HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Diseases associated with HDAC11 include Mature T-Cell And Nk-Cell Lymphoma and Peripheral T-Cell Lymphoma. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

Histone deacetylase 11 (HDAC11) is the least characterized of the human zinc-dependent HDACs. Here we provide insight into its enzymology at the molecular level by addressing its substrate specificity, enzyme kinetics, and susceptibility to a range of standard HDAC inhibitors in vitro. Based on our data, HDAC11 is the first isozyme of this ...

Histone deacetylase11 (HDAC11) is the newest member of the histone deacetylase (HDAC) family and the only class IV histone deacetylase. HDAC11 has different expression levels and biological functions in different systems of the human body and is among the top 1 to 4% of genes overexpressed in cancers, such as breast cancer, hepatocellular ...

HDAC11 shows tissue and cell type-specific expression, encompassing innate and adaptive immunity cell types. HDAC11 represses anti-inflammatory IL10 interleukin gene transcription. HDAC11 is involved in immune cell fate modulation since its knock-out in mice boosts certain T and neutrophil responses. Kumar D. Shanmukha, ...

5 days ago · Herein, we identified that HDAC11 is involved in the pathogenesis of AML and is a potential therapeutic target for AML. Considering the scarcity of HDAC11 inhibitors, structurally novel HDAC11 inhibitors were developed, identifying A9 as the most potent one, which phenocopied the apoptosis induction, cell cycle arrest, and differentiation promotion effects of HDAC11 knockdown in AML cells ...