Feb 8, 2025 · HDAC1 expression is positively correlated with NADPH oxidase 4-mediated oxidative stress in a mouse model of traumatic brain injury. Downregulation of Sp1 Inhibits the Expression of HDAC1/SOX10 to Alleviate Neuropathic Pain-like Behaviors after Spinal Nerve Ligation in Mice.

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. [5] Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression.

4 days ago · HDAC1 (10E2) Mouse mAb detects endogenous levels of total HDAC1 protein. The antibody does not cross-react with other HDAC proteins. Human, Mouse, Rat, Monkey. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human HDAC1 protein.

Jul 1, 2008 · HDAC1 is likely a major deacetylase in preimplantation embryos and its expression inversely correlates with changes in the acetylation state of histone H4K5 during preimplantation development.

Sep 24, 2019 · Mouse zygotes derived in vivo were microinjected with Hdac1/2 siRNA cocktails (20 µM, 10 pl, cKD) or negative control siRNAs (NC). Embryos were collected at 8-cell (8c), morula (M), and blastocyst (Bl) stage (n = 3 pools of 5–10 embryos each per treatment).

Apr 15, 2016 · HDAC1 and HDAC2 regulate oocyte development through transcription in a dosage-dependent manner. HDAC2 is the major HDAC in mouse oocytes and regulates global DNA methylation and imprinting...

Oct 2, 2018 · HDAC1 and HDAC2 (HDAC1/2) are highly related deacetylases that form the catalytic core of multiple co-repressor complexes, including, Sin3, NuRD, CoREST and MiDAC 19, 20. The complex is an...

Apr 15, 2016 · HDAC1 is the responsible HDAC involved in cell cycle regulation and zygotic genomic activation during preimplantation development. How do HDAC1 and HDAC2 regulate cross-talk between histone acetylation and other epigenetic modifications during oocyte and preimplantation embryo development?

Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (By similarity). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (By similarity).

Apr 20, 2001 · Previously, we have identified murine HDAC1 as a growth factor-inducible protein in murine T-cells. Here, we characterise the molecular function of mouse HDAC1 in more detail. Co-immunoprecipitation experiments with epitope-tagged HDAC1 protein reveal the association with endogenous HDAC1 enzyme.