May 18, 2020 · MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions. This enzyme is often diminished in both Alzheimer’s patients and normally aging adults.

May 18, 2020 · MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions. This enzyme is often diminished in both Alzheimer’s patients and normally aging adults.

Class I mammalian HDACs (HDAC1, HDAC2, HDAC3, and HDAC8) have sequence similarity to Rpd3 [10] protein: a molecule, belonging to Class I HDACs, responsible for the deacetylation of lysine residues on the N-terminal part of the core histones in yeast.

Jan 12, 2022 · Our results showed that both HDAC1 and HDAC2 are expressed in all cellular stages during hippocampal neurogenesis. Moreover, we found that deletion of HDAC1 by viral infection of neural stem cells is sufficient to compromise neuronal differentiation in vitro.

May 25, 2020 · An enzyme called OGG1 is responsible for repairing this type of oxidative DNA damage, and the researchers found that HDAC1 is needed to activate OGG1. When HDAC1 is missing, OGG1 fails to turn on and DNA damage goes unrepaired.

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. [5] Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression.

Dec 19, 2024 · Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on core histones, a critical step in regulating chromatin accessibility. Despite histone deacetylation being an apparently repressive activity, suppression of HDACs causes both up- and downregulation of gene expression.

Here, we investigate the impact of histone deacetylation on DCs by genetically deleting histone deacetylase 1 (HDAC1) or HDAC2 in hematopoietic progenitors and CD11c-expressing cells.

Jan 12, 2022 · Our results showed that both HDAC1 and HDAC2 are expressed in all cellular stages during hippocampal neurogenesis. Moreover, we found that deletion of HDAC1 by viral infection of neural stem cells is sufficient to compromise neuronal differentiation in vitro.

Mar 30, 2025 · HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. Diseases associated with HDAC1 include Hematologic Cancer and Epilepsy. Among its related pathways are RNA Polymerase I Promoter Opening and Transcriptional Regulation by MECP2.