Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand the key pathways regulated by HDAC1/2 in the adaptive immune system and inform their exploitation as drug targets, we have generated mice with a T cell specific deletion.

Oct 2, 2018 · Here we show that Histone Deacetylase 1 and 2 (HDAC1/2), the catalytic core of numerous co-repressor complexes, are important histone decrotonylase enzymes. A ternary complex of...

Class I mammalian HDACs (HDAC1, HDAC2, HDAC3, and HDAC8) have sequence similarity to Rpd3 protein: a molecule, belonging to Class I HDACs, responsible for the deacetylation of lysine residues on the N-terminal part of the core histones in yeast.

6 days ago · In sharp contrast, T cell-specific deletion of Hdac1 or Hdac2 in the ALCL mouse model significantly accelerated NPM::ALK-driven lymphomagenesis, with Hdac1 loss having a more pronounced effect.

Class I/II HDAC inhibitors block the activity of HDAC1 and HDAC2 resulting in defects in the DDR, including hyper-acetylation of H3K56 and H4K16 as well as an impairment of NHEJ. There are various ways in which HDAC1 and HDAC2 could influence NHEJ.

Jan 31, 2025 · Here, we revealed the novel role of the histone deacetylases HDAC1 and HDAC2 in histone acylation catalysis. Notably, we show that HDAC1 and HDAC2 directly catalyze sorbylation using sorbic acid, a common food preservative, in addition to facilitating desorbylation.

Jul 24, 2023 · Here we unveil a genetic interaction between histone deacetylase 1 (HDAC1) and HDAC2, wherein each paralog is synthetically lethal with hemizygous deletion of the other.

Sep 20, 2024 · Depletion of HDAC1 and HDAC2 (referred to as HDAC1/2) led to the increase of Wnt effectors, which induced NP-like cells. Furthermore, the prolonged existence of NP-like cells disrupts cortical organization.

DNA double-strand break (DSB) repair occurs within chromatin and can be modulated by chromatin-modifying enzymes. Here we identify the related human histone deacetylases HDAC1 and HDAC2 as two participants in the DNA-damage response.

Here, we investigate the impact of histone deacetylation on DCs by genetically deleting histone deacetylase 1 (HDAC1) or HDAC2 in hematopoietic progenitors and CD11c-expressing cells. While HDAC2 is not critical for DC development, HDAC1 deletion impairs pro-pDC and mature pDC generation and affects ESAM + cDC2 differentiation from tDCs and pre ...