Jul 29, 2019 · In the present study, treatment with the protein synthesis inhibitor CHX resulted in downregulation of HDAC1 in nondrug-resistant AML cells, but it had no effect on HDAC1 expression in drug-resistant AML cells.

May 11, 2021 · EGFR may phosphorylate HDAC1 at Tyr72 to stabilize HDAC1 by protecting it from ubiquitination, which in turn promotes cell survival and reduces apoptosis, whereas hypo-phosphorylation of...

Our results present evidence for a precise regulatory mechanism which allows induction of the HDAC1 gene in response to proliferation signals and modulation of HDAC1 expression dependent on intracellular deacetylase levels.

Dec 7, 2023 · In the present study, we designed a series of small-molecule Thiazole-based HDACis, among which HR488B bound to HDAC1 with a high affinity and exerted effective anti-CRC activity both in vitro...

Jul 11, 2022 · G, H Western blot detected HDAC1 levels in SK-N-AS and SK-N-SH cells transfected with Ctrl ASO or SNORA50C ASO#1 followed by CHX treatment at the indicated time points (left panel).

Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand the key pathways regulated by HDAC1/2 in the adaptive immune system and inform their ...

We discovered that HDAC1 activates PU.1 gene transcription via deacetylation of TATA-binding protein–associated factor 9 (TAF9), a component in the transcription factor IID (TFIID) complex. Treatment with HDAC inhibitor results in an increase in TAF9 acetylation.

CHX-treated neurons were further treated with SAHA, and the results showed that SAHA treatment markedly promoted the protein degradation of TDP-43 in neurons that were treated with CHX (Fig....

Sep 10, 2018 · In the present study, we demonstrate that NANOG stabilizes HDAC1 protein through the inactivation of CHFR, via NANOG-TCL1-pAKT axis and that the accumulation of HDAC1 results in CSC-like and multi-resistant phenotypes through its catalytic activity in immune-edited tumor cells.

Dec 25, 2024 · The LINC01094-miR-128-3p-RUNX1 feedback loop downregulates CDKN1A and promotes GC cooperatively with RBMS2 and HDAC1. Furthermore, Ro 5-3335 may hold promising therapeutic potential in the treatment of GC.