May 18, 2020 · HDAC1 stimulates OGG1, a DNA glycosylase known to remove 8-oxoG lesions that are associated with transcriptional repression. HDAC1 deficiency causes impaired OGG1 activity, 8-oxoG accumulation at...

May 24, 2024 · We wondered whether SIN3B, SIN3A, and HDAC1 binding to cell-cycle gene promoters in arrested HCT116 cells could be detected by ChIP. We performed ChIP-qPCR on samples from Idasanutlin-arrested...

Jul 8, 2019 · Combination of Merck60 (HDAC1 + 2i) and LW3 (HDAC3i) mimics the strong effect of triple HDAC1 + 2 + 3 inhibitor Entinostat.

Dec 10, 2011 · To further understand epigenetic phenomena that contribute to chromatin structure and regulate gene expression, we evaluated promoter occupancy of HDAC1 in ES and trophoblast stem (TS) cells using genome-wide chromatin immunoprecipitation followed by microarray analysis (ChIP-chip).

Mar 27, 2023 · Histone deacetylase 1 (Hdac1) plays a crucial role in maintaining differential histone acetylation states of enhancers in various germ layers and regulates the transcriptional program both temporally and spatially.

Jun 27, 2023 · To understand the role of HDACs in regulating the CLL transcriptome, we conducted chromatin immunoprecipitation (ChIP) and integrated the genome-wide recruitment of HDAC1, with BRD4, H3K27Ac, H3K9Ac, chromatin accessibility signatures, Pol2 occupancy, and target expression signatures.

Oct 2, 2018 · Here we show that Histone Deacetylase 1 and 2 (HDAC1/2), the catalytic core of numerous co-repressor complexes, are important histone decrotonylase enzymes. A ternary complex of HDAC1/CoREST1/LSD1 is able to hydrolyse both histone H3 Lys18-acetyl (H3K18ac) and H3 Lys18-crotonyl (H3K18cr) peptide substrates.

Mar 20, 2018 · To investigate how Hdac1 and Hdac2 deletion altered histone acetylation in microglia, we performed ChIP-seq analysis for H3K9 and H3K27 acetylation. We found significant enrichment of genes involved in phagocytosis or related pathways in FAD DKO animals compared to FAD (Figures S7 A and S7B).

Sep 20, 2024 · Depletion of HDAC1 and HDAC2 (referred to as HDAC1/2) led to the increase of Wnt effectors, which induced NP-like cells. Furthermore, the prolonged existence of NP-like cells disrupts cortical organization.

Dec 19, 2024 · Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on core histones, a critical step in regulating chromatin accessibility. Despite histone deacetylation being an apparently repressive activity, suppression of HDACs causes both up- and downregulation of gene expression.