CMCs depleted of HDAC1 exhibited induction of a cardiogenic transcriptional program characterized by enhanced expression of cardiomyogenic (MEF2C, NKX2.5, and TBX5)- and vasculogenic (CD31) factors.

Sep 5, 2020 · Our study revealed that Histone Deacetylase 1 (HDAC1) directly inhibits the ubiquitination of HIF1α. Additionally, HDAC1 activates HIF1α/VEGFA signaling pathway, promoting s tumor angiogenesis. These findings have enhanced our understanding of the molecular mechanisms of colorectal (CRC) tumor angiogenesis.

Multi-omics analyses reveal that HDAC1 controls expression, chromatin accessibility, and histone acetylation of the transcription factors IRF4, IRF8, and SPIB required for efficient development of cDC2 subsets.

Apr 1, 2023 · Rutin could alleviate EndMT and restore autophagy in vivo and in vitro models. Proteomics analysis results showed that HDAC1 significantly downregulated in the 200 mg/kg/d Rutin group compared with the db/db group. Transfection with si-HDAC1 in GEnCs partially blocked HG-induced EndMT and restored autophagy.

Jun 25, 2024 · Here, we investigate the impact of histone deacetylation on DCs by genetically deleting histone deacetylase 1 (HDAC1) or HDAC2 in hematopoietic progenitors and CD11c-expressing cells.

We found that although both HDAC1i and iBPP significantly decreased OC growth (Figure 4A and B), shown as decreased p‐HDAC1 and increased H3K27ac in ovaries (Figure 4C–E) and decreased CD31 and HE4 (Figure S8D–F), only iBPP recovered the number of follicles at each stage (Figure 4F–J) by downregulating p‐RPS6 and upregulating NNT ...

This study investigated whether and how the clinically available histone deacetylases 1 and 2 (HDAC1/2) inhibitor drug Romidepsin epigenetically modulates VCAM-1 expression to suppress atherosclerosis. Methods: VCAM-1 expression was analyzed in primary human aortic EC (HAEC) treated with Romidepsin or transfected with HDAC1/2-targeting siRNA.

Mocetinostat, an isoform-selective HDAC inhibitor, which specifically inhibits HDAC1, HDAC2, and HDAC3, was used to evaluate whether HDAC1-3 can mediate the protective effect of TSA.

Sep 1, 2016 · CMCs depleted of HDAC1 exhibited induction of a cardiogenic transcriptional program characterized by enhanced expression of cardiomyogenic (MEF2C, NKX2.5, and TBX5)- and vasculogenic (CD31) factors.

Mar 20, 2018 · Datta et al. show that histone deacetylases Hdac1 and Hdac2 are essential for microglial survival and expansion during development but not during steady state. In Alzheimer’s disease mouse model, deletion of microglial Hdac1 and Hdac2 reduces amyloid pathology and improves cognitive function.