May 11, 2021 · By deacetylating histones and non-histone proteins, HDAC1 has a profound effect on the regulation of gene transcription and many processes related to cell growth and cell death, including cell...

Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on core histones, a critical step in regulating chromatin accessibility. Despite histone deacetylation being an apparently repressive activity, suppression of HDACs causes both up- and downregulation of gene expression.

3 days ago · HDAC1 (10E2) Mouse mAb detects endogenous levels of total HDAC1 protein. The antibody does not cross-react with other HDAC proteins. Human, Mouse, Rat, Monkey. …

6 days ago · Histone Deacetylase 1 (HDAC1) Antibody detects endogenous levels of total HDAC1 protein. The antibody does not cross-react with other HDAC proteins.

Multi-omics analyses reveal that HDAC1 controls expression, chromatin accessibility, and histone acetylation of the transcription factors IRF4, IRF8, and SPIB required for efficient development of cDC2 subsets.

PA1-860 detects histone deacetylase 1 (HDAC1) from human, mouse, rat, hamster and canine tissues and cells. PA1-860 has been successfully used in Western blot, immunoprecipitation, ChIP, immunofluoresence, immunocytochemistry and immunohistochemistry procedures.

5 days ago · Western blotting Snap-frozen tissues were processed for SDS-PAGE and western blot analysis as previously described [19]. Antibodies and buffers are listed in Supplementary Methods. FACS ...

Figure 2 A selective class-I HDAC inhibitor overcomes ICB resistance in HCC models. (A) Western blot analysis of HDAC1, HDAC2 and HDAC3 levels in orthotopic Hepa1-6-PD-L1R (left) and RIL-175-PD-1R (right) tumour and non-tumour liver tissues isolated from mice. GAPDH was used as loading control.

1 day ago · Western blot analysis was performed using a SuperSignal™ West Dura Extended Duration substrate system (Thermo Fisher Scientific, Waltham, MA, USA) and a G:BOX Chemi XX6 gel documentation system ...

4 days ago · The Class I HDAC Antibody Sampler Kit provides an economical means of detecting Class I HDAC proteins using control antibodies against HDAC1, HDAC2 and HDAC3. The kit contains enough primary antibodies to perform at least two western blot experiments.