Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., sirtuins). [1]

The present studies confirm the potent dose-dependent antitumor activity of TSA against breast cancer in vitro and in vivo, strongly supporting HDAC as a molecular target for anticancer therapy in breast cancer.

Jan 26, 2018 · Trichostatin A (TSA) possess histone deacetylase (HDAC) inhibitory potential, can reverse the deactivation of tumor suppressor genes and inhibit tumor cell proliferation. We evaluated...

Suberoylanilide hydroxamic acid (SAHA/Vorinostat/Zolinza), Trichostatin A (TSA), and PXD-101 are hydroxamic acid-based pan-HDAC inhibitors. Depsipeptide (FK228/ romidepsin/ISTODAX®) is a natural cyclic peptide product of prodrug type, which inhibits HDAC1 and 2 selectively.

HDAC inhibitors have been described to alter non-coding RNA expression. TSA and SAHA induce miR-129-5p overexpression and apoptosis in thyroid cancer cells. miR-129-5p alone induces cell death and knockdown experiments showed that its expression is necessary for HDAC inhibitor-induced cell death .

HDAC activity is suppressed by TSA and sodium butyrate in HCC lead to the inhibition of invasion and metastasis by upregulation of early growth response claudin-3 and gene-1. HDACI sodium butyrate performs its anticancer effect by HDAC4 inhibition on …

Trichostatin A (TSA) is a noncompetitive, reversible inhibitor of class I and II histone deacetylases (HDACs). HDACs have been shown not only to deacetylate histones but also to target non-histone proteins involved in diverse signaling pathways.

Feb 15, 2007 · We report here that inhibition of HDAC activity by Trichostatin A (TSA) and sodium butyrate (NaBu), the two specific HDAC inhibitors, resulted in the elevation of both endogenous and exogenous activity of IL-5 promoter.

Oct 7, 2016 · Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC 50 value of 1.8 nM for HDAC. Trichostatin A (TSA) inhibits proliferation of eight breast carcinoma cell lines with mean±SD IC 50 of 124.4±120.4 nM (range, 26.4-308.1 nM).